2019 Aug 1
Department of Anatomy, College of Medicine, Yonsei University, Republic of Korea
The role of NOX inhibitors in neurodegenerative diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709343/
Abstract
Oxidative stress is a key player in both chronic and acute brain disease due to the higher metabolic demand of the brain. Among the producers of free radicals, NADPH-oxidase (NOX) is a major contributor to oxidative stress in neurological disorders. In the brain, the superoxide produced by NOX is mainly found in leukocytes. However, recent studies have reported that it can be found in several other cell types. NOX has been reported to regulate neuronal signaling, memory processing, and central cardiovascular homeostasis. However, overproduction of NOX can contribute to neurotoxicity, CNS degeneration, and cardiovascular disorders. Regarding the above functions, NOX has been shown to play a crucial role in chronic CNS diseases like Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and in acute CNS disorders such as stroke, spinal cord injury, traumatic brain injury (TBI), and related cerebrovascular diseases. NOX is a multi-subunit complex consisting of two membrane-associated and four cytosolic subunits. Thus, in recent years, inhibition of NOX activity has drawn a great deal of attention from researchers in the field of treating chronic and acute CNS disorders and preventing secondary complications. Mounting evidence has shown that NOX inhibition is neuroprotective and that inhibiting NOX in circulating immune cells can improve neurological disease conditions. This review summarizes recent studies on the therapeutic effects and pharmacological strategies regarding NOX inhibitors in chronic and acute brain diseases and focuses on the hurdles that should be overcome before their clinical implementation.
NOX inhibitors
NOX inhibitors
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Re: NOX inhibitors
yes, oxidative stress is a key player in many chronic (autoimmune) diseases.
and of course, inhibition of NOX can improve disease conditions.
I think the superoxide is produced by EBV B cells, to kill the pathogen.
For that the superoxide forms peroxynitrite locally, to obstruct the feeding of the virus.
And the mitochondria are affected as well detoriorating conditions for eg ATP generation.
And if the cellular pool of ATP goes down, the cell has a problem and its anti-viral properties will weaken.
and of course, inhibition of NOX can improve disease conditions.
I think the superoxide is produced by EBV B cells, to kill the pathogen.
For that the superoxide forms peroxynitrite locally, to obstruct the feeding of the virus.
And the mitochondria are affected as well detoriorating conditions for eg ATP generation.
And if the cellular pool of ATP goes down, the cell has a problem and its anti-viral properties will weaken.