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CCSVI reloaded. Brave Dreams data re-analysed.

Posted: Sun Nov 24, 2019 5:39 am
by frodo
Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial ... 2819890110


Expanded analysis of the Brave Dreams data that included secondary/progressive MS patients in addition to the relapsing/remitting patients analyzed previously showed that venoplasty decreases new cerebral lesions at 1 year.

Secondary analysis confirmed the efficacy of the Giaquinta grading system in selecting patients appropriate for venoplasty who were more likely to be free from accumulation of new cerebral lesions at MRI.

Re: CCSVI reloaded. Brave Dreams data re-analysed.

Posted: Fri Nov 29, 2019 11:28 am
by Petr75
Department of Anatomy, University of Opole, Opole, Poland
Potential Involvement of Impaired Venous Outflow from the Brain in Neurodegeneration: Lessons Learned from the Research on Chronic Cerebrospinal Venous Insufficiency.

About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer's and Parkinson's diseases. Although direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps an abnormal venous drainage of the brain affects functioning of the glymphatic system, which in turn results in the accumulation of pathological proteins in the cerebral tissue (such as β-synuclein, β-amyloid and α-synuclein) and triggers the venous outflow from the cranial cavity and circulation of the cerebrospinal fluid in the settings of neurodegenerative disease.

More data supporting venoplasty in MS

Posted: Thu Dec 12, 2019 2:18 am
by frodo
Thanks Petr75. Quite interesting.

Today there is new data supporting venoplasty in MS:

Mid-term Improvement of Persistent Headaches in Patients with Multiple Sclerosis Underwent Balloon Venoplasty of Internal Jugular Veins ... via%3Dihub

Results -

With the exception of the PP patients there were significant reductions (all p < 0.001) in the MIDAS score in the 3-month following PTA. The clinical improvement in MIDAS score following venoplasty was maintained throughout the follow-up period in both the RR (p < 0.001; mean of 3.55 years) and SP (p = 0.002; mean of 3.52 years) MS cohorts (Figure 1). Furthermore post-venoplasty MIDAS score was significantly negatively correlated with the change in the blood flow score in the left (r = -0.238, p = 0.031) and right (r = -0.250, p = 0.023) IJVs in the RR patients and left IJV (r = -0.727, p = 0.026) in the PP patients.