Oxidative Stress

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Petr75
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Oxidative Stress

Post by Petr75 »

2020 Feb 13
Department of Integrative and Functional Genomics, CSIR- Institute of Genomics and Integrative Biology, New Delhi, India
Oxidative Stress in Autoimmune Diseases: An Under Dealt Malice
https://pubmed.ncbi.nlm.nih.gov/3205652 ... lt-malice/


Abstract

Oxidative stress is the off-balance of antioxidants and free radicals. All kinds of disease and disorders give rise to oxidative damage including autoimmune diseases. An autoimmune disorder is a pathological condition characterized by the breakdown of self-tolerance of the immune system in the body. Immunological processes against tissues and organs leading to enhanced oxidative stress and in turn, misbalance of oxidative stress aggravates the pathobiology of the disease. Highly reactive nature of free radicals, for example, hydroxyl, superoxide ions, alter DNA, protein, and lipids in the body which augments the pathologic processes of diseases. The damaged biomolecules are responsible for systemic complications and secondary disease co-morbidities. In this review, we discuss the role of oxidative stress in some incapacitating autoimmune diseases like Rheumatoid arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis. Oxidative stress plays a central and course defining role in these diseases and it becomes a necessity to study the pathological mechanism involved around oxidative stress to better understand and offer treatment holistically. Presently there are no clinically available parameters for measurement and treatment for pathological oxidative stress, therefore it requires intensive research. Probably, in the future, the discovery of easily detectable markers of oxidative stress can aid in the diagnosis, prognosis, and treatment of progressively destructive autoimmune diseases. Keywords: Autoimmune diseases, oxidative stress, reactive oxygen species, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis.
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Petr75
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Re: Oxidative Stress

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2020 Mar 11
Acharya & BM Reddy College of Pharmacy, Bengaluru, India
Neurodegeneration by Oxidative Stress: A Review on Prospective Use of Small Molecules for Neuroprotection
https://pubmed.ncbi.nlm.nih.gov/32162127/

Abstract

The intricate physiology of many Central Nervous System (CNS) disorders points towards oxidative damages of neurons. Various studies have established that oxidative stress is a big threat to integrity of neurons. All the sections of central nervous system are exposed to free radicals and charged species formed during oxidative degradation of catecholamines and polyunsaturated fatty acids which are present abundantly in CNS. By products of other biochemical reactions also contribute to oxidative stress in central nervous system. If these charged species are not counter neutralized by antioxidants, it leads to neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, Amyotropic lateral sclerosis, Multiple sclerosis, Spinal cord injury, Schizophrenia etc. The level of charged species and free radicals is found to be higher in neurodegenerative diseases than normal physiological condition and it is related to oxidative damages to neuronal cells. In many of such cases, use of antioxidants decreases oxidative stress and contribute to neuroprotection. This review intends to compile approach of managing oxidative stress in various neurodegenerative disorders. The perspective of this review is to study antioxidants and their role in neuroprotection.
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Petr75
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Re: Oxidative Stress

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2020 Apr 24
Department for Life Quality Studies, University of Bologna, Rimini, Italy
Oxidative Stress in Neurodegenerative Diseases: From Preclinical Studies to Clinical Applications.
https://www.researchgate.net/publicatio ... plications

https://www.ncbi.nlm.nih.gov/pubmed/32344515

Abstract
Oxidative stress plays an important role in the pathogenesis of several different neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS)
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Petr75
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Re: Oxidative Stress

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2020 Aug 7
San Diego, California
Oxidative/Nitroxidative Stress and Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/32767188/


Abstract

Multiple sclerosis (MS) is a multifactorial, central nervous system, immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration. Evidence suggests a steady rise in MS prevalence over the past five decades in the United States and around the world. Even with increased understanding of immunology, the specific etiological trigger of MS remains unknown. Evidence suggests that oxidative/nitroxidative stress is an important contributor to MS etiology, progression, and clinical symptoms. A multifaceted treatment approach aimed at counteracting oxidative/nitroxidative stress including MS disease-modifying medications, Mediterranean style diet, stress-relieving activities, smoking and alcohol cessation, exercise, and peer support programs is the best way to treat the disease.
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