Fingolimod better than interferon beta and GA

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frodo
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Fingolimod better than interferon beta and GA

Post by frodo »

Disability progression in relapse-free multiple sclerosis patients on fingolimod versus interferon-beta/glatiramer acetate

https://journals.sagepub.com/doi/abs/10 ... 8520918489

Abstract

Background:

Disability progression independent of relapses (PIRA) has been described as a frequent phenomenon in relapsing-remitting multiple sclerosis (RRMS).
Objective:

To compare the occurrence of disability progression in relapse-free RRMS patients on interferon-beta/glatiramer acetate (IFN/GA) versus fingolimod.
Methods:

This study is based on data from the Swiss association for joint tasks of health insurers. Time to relapse and 12-month confirmed disability progression were compared between treatment groups using multivariable Cox regression analysis with confounder adjustment. Inverse-probability weighting was applied to correct for the bias that patients on fingolimod have a higher chance to remain relapse-free than patients on IFN/GA.
Results:

We included 1640 patients (64% IFN/GA, 36% fingolimod, median total follow-up time = 4–5 years). Disease-modifying treatment (DMT) groups were well balanced with regard to potential confounders. Disability progression was observed in 155 patients (8.8%) on IFN/GA and 51 (7.6%) on fingolimod, of which 44 and 23 were relapse-free during the initial DMT, respectively. Adjusted standard regression analysis on all patients indicated that those on fingolimod experience less frequently disability progression compared with IFN/GA (hazard ratio = 0.53 (95% confidence interval = 0.37–0.76)). After bias correction, this was also true for patients without relapses (hazard ratio=0.56 (95% confidence interval = 0.32–0.98).
Conclusion:

Our analysis indicates that fingolimod is superior to IFN/GA in preventing disability progression in both relapsing and relapse-free, young, newly diagnosed RRMS patients.
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gibbledygook
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Re: Fingolimod better than interferon beta and GA

Post by gibbledygook »

If my experience is anything to go by, I would definitely agree that Fingolimod is better than beta interferon. I've been on Fingolimod since around 2013 and I basically haven't had a relapse since then. I also started in around 2016 to take Trazodone which is a sleeping tablet/anti depressant which is said to have neurite sprouting effects. I also went for the bilateral jugular stenting at Stanford which had a wonderful but short-lived effect. I then had a stent placed in a vein for Nutcracker syndrome but this had a powerfully negative effect on my symptoms triggering a relapse after which I went on Fingolimod.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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