2020 Jul 29
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
An atlas on risk factors for multiple sclerosis: a Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/32728946/
Abstract
Objectives: We conducted a systematic review and wide-angled Mendelian randomization (MR) study to examine the association between possible risk factors and multiple sclerosis (MS).
Methods: We used MR analysis to assess the associations between 65 possible risk factors and MS using data from a genome-wide association study including 14 498 cases and 24 091 controls of European ancestry. For 18 exposures not suitable for MR analysis, we conducted a systematic review to obtain the latest meta-analyses evidence on their associations with MS.
Results: Childhood and adulthood body mass index were positively associated with MS, whereas physical activity and serum 25-hydroxyvitamin D were inversely associated with MS. There was evidence of possible associations of type 2 diabetes, waist circumference, body fat percentage, age of puberty and high-density lipoprotein cholesterol. Data of systematic review showed that exposure to organic solvents, Epstein Barr virus and cytomegalovirus virus infection, and diphtheria and tetanus vaccination were associated with MS risk.
Conclusions: This study identified several modifiable risk factors for primary prevention of MS that should inform public health policy.
An atlas on risk factors
An atlas on risk factors
https://www.eboro.cz
Re: An atlas on risk factors
Read my thesis on viewtopic.php?f=1&t=15188&start=900#p260052 for a broader perspective on things. This Swedish atlas is kindergarten stuff just adding to the confusion.
A new global cognition is developing outside traditional circles, on the Internet, in weekly meetings of groups of professionals with global participation via Zoom, and in fact here on TIMS. The horizon extends way beyond old thinking.
With the thesis now in global circulation, the ghost is out of the bottle, they will never get it back in. It is therefore no longer a matter if, but only a matter when.
A new global cognition is developing outside traditional circles, on the Internet, in weekly meetings of groups of professionals with global participation via Zoom, and in fact here on TIMS. The horizon extends way beyond old thinking.
With the thesis now in global circulation, the ghost is out of the bottle, they will never get it back in. It is therefore no longer a matter if, but only a matter when.
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