diet, hormones, aging, immune function

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jimmylegs
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diet, hormones, aging, immune function

Post by jimmylegs »

i've been doing some reading re 2:16alphahydroxyestrone ratios in health and disease. interesting info at this link, but i'm still very early in this learning curve...

Estrone Derivative
https://www.sciencedirect.com/topics/ph ... derivative

Sex Steroids and Immunity
Sex Hormones and Immune Function
Hormones and Cytokines
Hormonal Effects on Immune System
Breast Cancer
>2-Hydroxyestrone/16-Hydroxyestrone Ratio
Gender and Age in Lupus
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jimmylegs
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testosterone and ms

Post by jimmylegs »

still just in the shallow end...

Testosterone Treatment in Multiple Sclerosis
A Pilot Study
https://jamanetwork.com/journals/jamane ... act/793883

... Results One year of treatment with testosterone gel was associated with improvement in cognitive performance (P = .008) and a slowing of brain atrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) was increased (P = .02).

Conclusion These exploratory findings suggest that testosterone treatment is safe and well tolerated and has potential neuroprotective effects in men with relapsing-remitting MS.
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jimmylegs
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women's sex hormones and ms

Post by jimmylegs »

the section snippets thing is kind of weird, but interesting content for what's there:

The role of sex hormones in women with multiple sclerosis: From puberty to assisted reproductive techniques (2021)
https://www.sciencedirect.com/science/a ... 2220300807
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SeXX Matters in Multiple Sclerosis

Post by jimmylegs »

haven't read this one yet, just browsing...

SeXX Matters in Multiple Sclerosis (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347971/
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Re: diet, hormones, immune function

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Serum Lipoprotein Profile Is Associated With Protective Effects of Oral Contraceptive Use on Multiple Sclerosis Severity: A Cross-Sectional Study (2019)
https://www.frontiersin.org/articles/10 ... 00060/full

"...Serum lipid profile is associated with protective effects of OC use on disability of RRMS patients. Lipoprotein metabolism may be involved in the modulatory effects of sex steroids on the severity of the disease."
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Re: diet, hormones, immune function

Post by jimmylegs »

not ms but

Zinc as a nutritional approach to bone loss prevention in an ovariectomized rat model
https://journals.lww.com/menopausejourn ... ss.13.aspx
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Re: diet, hormones, immune function

Post by jimmylegs »

a little random but

Bone Health in Aging Men: Does Zinc and Cuprum Level Matter?
https://www.mdpi.com/2218-273X/11/2/237/htm

"... Our results suggest that the Zn/Cu ratio in both the serum and the bone may exert a significant positive effect on total BMD and BMC"
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Re: diet, hormones, immune function

Post by jimmylegs »

The State of Men's Health: Andropause
https://msfocus.org/Magazine/Magazine-I ... Andropause

Testosterone therapy has proven effective in relieving andropausal symptoms, usually within three to six weeks’ time. ...
It is important to realize that changes in libido, increased fatigue and decreased physical agility are also symptoms of MS. For that reason, a diagnosis of andropause may be overlooked. After your next blood work and physical exam, ask your doctor if you might be a suitable candidate for testosterone replacement.
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Re: diet, hormones, immune function

Post by jimmylegs »

Low testosterone is associated with disability in men with multiple sclerosis
https://journals.sagepub.com/doi/abs/10 ... 8514527864
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Re: diet, hormones, immune function

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Hormone therapy use and physical quality of life in postmenopausal women with multiple sclerosis (2016)
https://n.neurology.org/content/87/14/1457.short

"... Systemic HT use was associated with better physical QOL in postmenopausal women with MS in this observational study. Further studies are necessary to investigate causality."
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Re: diet, hormones, immune function

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Vitamin D3 Confers Protection from Autoimmune Encephalomyelitis Only in Female Mice (2005)
https://www.jimmunol.org/content/jimmun ... 9.full.pdf

"The prevalence of multiple sclerosis (MS) increases significantly with decreasing UV B light exposure, possibly reflecting a
protective effect of vitamin D3. ... The intact, vitamin D3-fed female mice had significantly less clinical, histopathological, and immunological signs of EAE than ovariectomized females or intact or castrated males. Correlating with reduced EAE, the intact, vitamin D3-fed female mice had significantly more 1,25-dihydroxyvitamin D3 and fewer CYP24A1 transcripts, encoding the 1,25-dihydroxyvitamin D3-inactivating enzyme, in the spinal cord than the other groups of mice. Thus, there was an unexpected synergy between vitamin D3 and ovarian tissue with regard to EAE inhibition. ... If humans have a similar gender difference in vitamin D3 metabolism in the CNS, then sunlight deprivation would increase the MS risk more significantly in women than in men, which may contribute to the unexplained higher MS incidence in women than in men..."
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diet, hormones, aging, immune function

Post by jimmylegs »

Testosterone and estrogen in multiple sclerosis: from pathophysiology to therapeutics (2018)
https://www.tandfonline.com/doi/abs/10. ... 18.1481390
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Re: diet, hormones, aging, immune function

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Gender Differences in Multiple Sclerosis: Induction of Estrogen Signaling in Male and Progesterone Signaling in Female Lesions
https://academic.oup.com/jnen/article/7 ... login=true

"... Together, these findings suggest that there are gender differences in the CNS of MS patients that may affect lesion pathogenesis, that is, in males, estrogen synthesis and signaling are induced; whereas in females, progestogen synthesis and signaling are induced. These differences may represent contributing factors to gender differences in the prevalence and course of MS."
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Jaded
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Re: SeXX Matters in Multiple Sclerosis

Post by Jaded »

jimmylegs wrote: Sun May 09, 2021 6:36 am haven't read this one yet, just browsing...

SeXX Matters in Multiple Sclerosis (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347971/
This is really interesting JL - thanks. So in EAE the use of progesterone diminishines myelin damage, etc

I wish docs were better informed - this might help a lot of women whose MS worsens during and after menopause

I was aware that hormone therapy would help - thought it was just the oestrogen

J
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Re: diet, hormones, aging, immune function

Post by Scott1 »

That article has six references in it to this researcher. She was interviewed by two MS groups a few months ago .
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