Bacillus coagulans

[Petr75]

2021 Nov 10
Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Iran
A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile
https://pubmed.ncbi.nlm.nih.gov/34757579/

Abstract

Multiple sclerosis is an inflammatory demyelinating disease that commences to neuronal cell destruction. Recently, a promising evidence of synergic effects of combined supplementation with vitamin D and probiotics in modulating the gut microbiota and metabolome is emerging. Bacillus Coagulans IBRC-M10791 as a novel strain was chosen, prevention and treatment impacts of regular administered were studied in Cuprizone-induced C57bl/6 mouse of demyelination. The mice were divided into six groups and received a daily dose of cuprizone or probiotics. To investigate the effect of probiotic, the IDO-1, CYP27B1, NLRP1, NLRP3, and AIM2 expression were estimated by Real-Time PCR, and IL-4, IL-17, IFN-gamma, and TGF-beta cytokines were measured by ELISA. The results showed that there was significant decrease in IL-17 and IFN-γ and modulatory effects on IL-4 and TGF-β. On the other hand, we demonstrated that there are significant decrease for expression of IDO-1, CYP27b1, NLRP1, NLRP3 and AIM2 genes in prevention and treatment groups compared to cuprizone group. Also, a significant enhancement in rate of remyelination and alternations proved by LFB staining and Y-Maze test. In conclusion, our study provides insight into how the therapeutic effect of the chosen strain of probiotic was correlated with the modulation of the level of inflammatory and anti-inflammatory cytokines. Further, we demonstrated that the expression of genes related to Tryptophan, Vitamin D and Inflammasome pathways could be affected by B.coagulans. Our study could be beneficial to provide a novel Co-therapeutic strategy for Multiple sclerosis.

[DIM]

Ever since my wife started taking high doses of probiotics (400 billion a day for months*) she has a noticeable difference in every aspect, and it seems that all other supplements she is taking, for a long time, have started to work!
I highly recommend anyone with mobility problems to try probiotic megadoses for a few months, he will definitely have an edss improvement!

*Strains in her probiotics:
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus delbrueckii susp. bulgaricus
Bifidobacterium longum susp. Longum (B.longum)
Lactobacillus rhamnosus
Streptococcus thermophilus
Bifidobacterium bifidum
Lactobacillus casei
Lactobacillus salivarius
Lactobacillus reuteri
Bifidobacterium animalis ( B.lactis)
Bifidobacterium breve
Bifidobacterium longum susp. Infantis (B.infantis)
Lactococcus lactis susb.lactis

Fructooligosaccharides (FOS) 50 mg

[DIM]

Bacillus Coagulans 25 billion:
https://www.physis-nutrition.com/produc ... illion-cfu

[NHE]

Bacillus Coagulans 25 billion:
https://www.physis-nutrition.com/produc ... illion-cfu

That page lists the supplement as 60 capsules at 500 million CFUs. To get 25 billion CFUs one would need to take 50 capsules.

[DIM]

Bacillus Coagulans 25 billion:
https://www.physis-nutrition.com/produc ... illion-cfu

That page lists the supplement as 60 capsules at 500 million CFUs. To get 25 billion CFUs one would need to take 50 capsules.

You are right, there are Swanson, Solaray, and 88herb (https://www.walmart.ca/en/ip/88Herbs-Pr ... DP5K1PL6N9) and many other brands that are more potent than the above.