p21-activated kinases (PAKs)

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.
Post Reply
User avatar
Petr75
Family Elder
Posts: 1318
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic
Contact:

p21-activated kinases (PAKs)

Post by Petr75 » Thu Nov 25, 2021 4:40 am

2021 Nov 22
Department of Neurology, Shriners Hospitals for Children/School of Medicine, Institute for Pediatric Regenerative Medicine (IPRM), University of California, U.S.A.
Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how
https://pubmed.ncbi.nlm.nih.gov/34811887/

Abstract

p21-activated kinases (PAKs) are a family of cell division control protein 42/ras-related C3 botulinum toxin substrate 1 (Cdc42/Rac1)-activated serine/threonine kinases. Group I PAKs (PAK1-3) have distinct activation mechanisms from group II PAKs (PAK4-6) and are the focus of this review. In transformed cancer cells, PAKs regulate a variety of cellular processes and molecular pathways which are also important for myelin formation and repair in the central nervous system (CNS). De novo mutations in group I PAKs are frequently seen in children with neurodevelopmental defects and white matter anomalies. Group I PAKs regulate virtually every aspect of neuronal development and function. Yet their functions in CNS myelination and remyelination remain incompletely defined. Herein, we highlight the current understanding of PAKs in regulating cellular and molecular pathways and discuss the status of PAK-regulated pathways in oligodendrocyte development. We point out outstanding questions and future directions in the research field of group I PAKs and oligodendrocyte development.
https://www.eboro.cz/ms/

Post Reply
  • Similar Topics
    Replies
    Views
    Last post

Return to “General Discussion”