The Potential Role of SARS-CoV-2 Infection and Vaccines in Multiple Sclerosis Onset and Reactivation: A Case Series and Literature Review.
Viruses. 2023 Jul 18;15(7):1569.
https://pubmed.ncbi.nlm.nih.gov/37515255/
The recent SARS-CoV-2 pandemic and related vaccines have raised several issues. Among them, the potential role of the viral infection (COVID-19) or anti-SARS-CoV-2 vaccines as causal factors of dysimmune CNS disorders, as well as the safety and efficacy of vaccines in patients affected by such diseases and on immune-active treatments have been analyzed. The aim is to better understand the relationship between SARS-CoV-2 infection/vaccines with dysimmune CNS diseases by describing 12 cases of multiple sclerosis/myelitis onset or reactivation after exposure to SARS-CoV-2 infection/vaccines and reviewing all published case reports or case series in which MS onset or reactivation was temporally associated with either COVID-19 (8 case reports, 3 case series) or anti-SARS-CoV-2 vaccines (13 case reports, 6 case series). All the cases share a temporal association between viral/vaccine exposure and symptoms onset. This finding, together with direct or immune-based mechanisms described both during COVID-19 and MS, claims in favor of a role for SARS-CoV-2 infection/vaccines in unmasking dysimmune CNS disorders. The most common clinical presentations involve the optic nerve, brainstem and spinal cord. The preferential tropism of the virus together with the presence of some host-related genetic/immune factors might predispose to the involvement of specific CNS districts.
Free full text.
New-Onset and Flares of Multiple Sclerosis are Associated with SARS-CoV-2 Infection and COVID-19 Vaccination
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 1409 Views
-
Last post by frodo
-
- 0 Replies
- 1755 Views
-
Last post by frodo
-
- 1 Replies
- 1936 Views
-
Last post by frodo
-
- 0 Replies
- 1781 Views
-
Last post by frodo
-
- 0 Replies
- 1916 Views
-
Last post by frodo
-
- 0 Replies
- 3818 Views
-
Last post by frodo
-
- 0 Replies
- 2075 Views
-
Last post by NHE
-
- 0 Replies
- 2466 Views
-
Last post by frodo
-
- 0 Replies
- 1769 Views
-
Last post by frodo