Jana,
You are correct in that there is a study investigating the situation
http://tinyurl.com/38k8bo
This is from 2006 Multiple Sclerosis Magazine "Oral Presentations-young researchers-session I"???
P475
Cancer incidence in multiple sclerosis: annual report of the
CARIMS cohort
C. Lebrun, M. Debouverie, P. Vermersch, P. Clavelou, L. Rumbach, J.
Deseze, G. Defer, D. Aufauvre, R. Deschamps, F. Berthier, A. Danzon on
behalf of the Club Francophone de la SEP
Background: Controversial results have been published between
cancer risk was not increased but female MS patients has an
increased risk of breast cancer. All except one published studies do
not consider potential risk factors such as medication, smoking and
diet. Objective: To evaluate Cancer Risk In Multiple Sclerosis
Cohort (CARIMS). To collect and study in 8 French MS centers the
patients’ profil with an history of cancer and multiple sclerosis.
Methods: Prospective study on MS patients with a documented
oncological event. Standardized incidence ratios were assessed to
compare observed number of cancer with expected in the general
population, as measure of relative risk. Data from the FRANCIM
network of French population-based Cancer Registries (available
from period 1975 2000) were used as reference. Results: 7322
MS patients were gathered: 117 patients (1,6%) with definite MS and
cancer; 100 women, 17 men with mean age at MS diagnosis: 37 yrs,
compared to 32.4 yr for the non cancer patients (pB/0.0001). MS
forms were RR 64%, SP 34%, PP 19%. Mean age at cancer diagnosis
was 46.2 yr. 17 patients had an history of cancer before MS
diagnosis and 100 after MS diagnosis. 22 patients (19%) had familial
relevant history of cancer and 5 of MS. Cancer was diagnosed in 53
patients (47%) without history of modifying disease treatments.
Histologies were breast cancer (37%), gynecologic: ovarian, cervix,
uterin (24%), skin (9%), acute leukemia (5%), colonic (6%), kidney
and bladder (5%), lung (2.6%), digestive (2.6%). Cancer’s location and frequencies had no specificity compared with non MS patients,
excepted for the age incidence. Free interval from MS diagnosis to
cancer was 7.3 yrs (/23//34). Female patients had more cancers
than males (RR: 2.35 vs; p/0.0022). PP and SP patients had a higher
cancer risk than RR patients (RR: 2.03; p/0.0004). Standardized
incidence rates calculated for all MS associated with cancer were
0.11 for men and 0.67 for women. Conclusions: According to the
recent literature, overall incidence of cancer in our MS population is
lower than expected in the general population. Matched to age,
gender, MS form and histologies of French Cancer Registry, cancer
in MS is associated with young age, female gender, SPMS form and
familial history of cancer.
Pubmed also spit these two out
http://tinyurl.com/2qz2qx
http://tinyurl.com/2sho8r