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There are two powerful opioid antagonists: 1) naloxone (Narcan) given as an injection or nasal spray in the case of narcotic overdose and 2) naltrexone administered orally in the treatment of alcohol dependence and to block opioid activity in the brain. There is a growing interest in low dose naltrexone (LDN). Doses range from 3 to 4.5 mg instead of the standard 50 mg dose. At this low dose, there are reports that the drug can help treat a range of health problems with minimal side effects (Clinical Rheumatology, online, Feb. 15, 2014). These are off-label uses not approved by the FDA. They include chronic pain as well as the pain and inflammation of fibromyalgia, Crohn’s disease and multiple sclerosis.