Immunological and clinical consequences of treating a patient with natalizumab
Abstract
Background: Long-term therapy with natalizumab increases the risk of progressive multifocal leukoencephalopathy (PML).
Objectives: We present a patient study through therapy, the diagnosis of PML (after 29 infusions), plasma exchange (PE) and development of immune reconstitution inflammatory syndrome (IRIS).... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1768
Immunological and clinical consequences of Tysabri
Immunological and clinical consequences of Tysabri
MS-UK - http://www.ms-uk.org/
Re: Immunological and clinical consequences of Tysabri
Additional info from the abstract...
NHEWith no clinical, routine laboratory or cerebrospinal fluid (CSF) changes, MRI 2 months after PE demonstrated progressive lesion development. Brain histopathology confirmed the presence of infiltrates indicative of IRIS without clinical signs, immunologically accompanied by CCR7/CCR5 recovery of peripheral monocytes.
Conclusion: Natalizumab-associated immunological changes accompanying PML were reversible after PE; IRIS can occur very late, remain asymptomatic and be elusive to CSF analysis.
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