I'm new here so apologise if this has already been covered somewhere but I'd like to ask if anyone else has elevated IgM levels. Mine are way over the limit and keep rising. The neuro I saw seemed very concerned about it without being very forthcoming as to why. So I got to researching and found the following article:
NIH Grant to Study IgM Antibodies in MS
The National Institutes of Health has awarded a $980,000 grant for collaborative research on a class of human IgM antibodies in multiple sclerosis. The grant is given to Acorda Therapeutics will fund research by Allan Bieber, PhD, and Moses Rodriguez, MD of the Mayo Clinic, Rochester, Minnesota.
The two-year grant is a Phase II Small Business Technology Transfer (STTR) grant. Acorda received a Phase I STTR grant from the NIH, and with that tested two antibodies, sHIgM22 and sHIgM46, using a widely accepted mouse model for MS. Mice were injected with a virus that causes demyelination in the nervous system similar to that seen with MS in humans. After demyelination started, the mice were then treated with the two antibodies, produced a strong remyelination.
If similar results are seen in more studies, Acorda is expected to file an investigational new drug application with the Food and Drug Administration to begin clinical testing of these antibodies in people.
"Our results indicate that these antibodies are part of the normal immune response in humans that may help protect and repair the brain and spinal cord from injury," says Dr. Rodriguez, who is Professor of Neurology and Immunology at the Mayo Medical School in Rochester.
Demyelination of nerves is the damage that leads to the disabilities associated with MS. Therapies that are currently approved work by slowing the progression of the disease but do affect demyelination of the nerves. The two antibodies being studied appear to stimulate the regrowth of myelin, providing a different of therapeutic approach for treating of MS.
Acorda, located in Hawthorne, NY, is a privately held biotechnology company, which is developing therapies for spinal cord injury and other neurological conditions, including MS.
If these antibodies are responsible for stimulating the regrowth of myelin shouldn't I be jumping for joy at my elevated levels?
Can anyone shed any light on this for me?
Does anyone else have really high IgM levels?
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Last post by frodo
Fri Jul 09, 2021 2:53 pm