Research: Exercise and Physiotherapy for MS

Using exercise and physical therapy for recovery from the effects of MS, and for maintaining physical function.
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Petr75
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Re: Research: Exercise and Physiotherapy for MS

Post by Petr75 » Fri Mar 12, 2021 10:31 am

2021 Jan 28
Department for Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany
Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/33633658/

Abstract

Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous exercise. This study (i) compares the effects of a 3-week HIIT and moderate continuous exercise training on cognitive performance and cardiorespiratory fitness of pwMS in an overall analysis and (ii) investigates potential effects based on baseline cognitive status in a subgroup analysis. Methods: Seventy-five pwMS were randomly assigned to an intervention (HIIT: 5 × 1.5-min intervals at 95-100% HRmax, 3 ×/week) or active control group (CG: 24 min continuous exercise at 65% HRmax, 3 ×/week). Cognitive performance was assessed pre- and post-intervention with the Brief International Cognitive Assessment for MS (BICAMS). (I) To examine potential within (time) and interaction (time × group) effects in the overall analysis, separate analyses of covariance (ANCOVA) were conducted. (II) For the subgroup analysis, participants were divided into two groups [intact cognition or impaired cognition (>1.5 standard deviation (SD) compared to healthy, age-matched norm data in at least one of the three tests of the BICAMS]. Potential impacts of cognitive status and intervention were investigated with multivariate analyses of variance (MANOVA). Results: Overall analysis revealed significant time effects for processing speed, verbal learning, rel. VO2peak, and rel. power output. A time*group interaction effect was observed for rel. power output. Subgroup analysis indicated a significant main effect for cognition (impaired cognition vs. intact cognition). Subsequent post-hoc analysis showed significant larger effects on verbal learning in pwMS with impaired cognition. Conclusion: Current results need to be confirmed in a powered randomized controlled trial with cognitive performance as primary endpoint and eligibility based on cognitive performance that is assessed prior to study inclusion.
https://www.eboro.cz/ms/

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Petr75
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Posts: 1219
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic
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Re: Research: Exercise and Physiotherapy for MS

Post by Petr75 » Sun Apr 04, 2021 4:51 am

2021 Mar 26
Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/33810574/

2021 Mar 16
Physical Exercise Moderates the Effects of Disability on Depression in People with Multiple Sclerosis during the COVID-19 Outbreak https://pubmed.ncbi.nlm.nih.gov/33809698/

2021 Mar 16
Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota
https://pubmed.ncbi.nlm.nih.gov/33796102/
https://www.eboro.cz/ms/

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Petr75
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Posts: 1219
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic
Contact:

Re: Research: Exercise and Physiotherapy for MS

Post by Petr75 » Fri May 07, 2021 5:00 am

2021 May 6
Department of Sport Physiology, Tarbiat Modares University, Tehran, Iran
Physical activity may contribute to brain health in multiple sclerosis: An MR volumetric and spectroscopy study
https://pubmed.ncbi.nlm.nih.gov/33955618/

Abstract

Background and purpose: Physical activity may represent a disease-modifying therapy in persons with multiple sclerosis (pwMS). To date, there is limited research regarding mechanisms based on brain imaging for understanding the beneficial effects of physical activity in pwMS. This study examined the relationship between physical activity levels and thalamic and hippocampal volumes and brain metabolism in pwMS.

Methods: The sample of 52 pwMS (37.3 ± 9.6 years of age; 35 females, 17 males) underwent a combination of volumetric magnetic resonance imaging and magnetic resonance spectroscopy. Current and lifetime physical activity were assessed using actigraphy and the adapted version of the Historical Activity Questionnaire, respectively.

Results: Positive associations were observed between both actigraphy and self-reported levels of moderate-to-vigorous physical activity (MVPA) and thalamic and hippocampal volumes. Regarding brain metabolism, actigraphy and self-reported levels of MVPA were positively associated with higher hippocampal and thalamic levels of N-acetylaspartate/creatine ratio (NAA/Cr: marker of neural integrity and cell energy state).

Conclusions: This study provides novel evidence for a positive association between physical activity and thalamic and hippocampal volume and metabolism in pwMS. These findings support the hypothesis that physical activity, particularly MVPA, may serve as a disease-modifying treatment by improving brain health in pwMS.
https://www.eboro.cz/ms/

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