Exercise plasma boosts memory and dampens brain inflammation via clusterin
Nature. 2021 Dec;600(7889):494-499.
Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the hippocampus2-4, yet little is known about the factors and mechanisms that mediate these effects. Here we show that 'runner plasma', collected from voluntarily running mice and infused into sedentary mice, reduces baseline neuroinflammatory gene expression and experimentally induced brain inflammation. Plasma proteomic analysis revealed a concerted increase in complement cascade inhibitors including clusterin (CLU). Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer's disease. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. These findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans who engage in exercise.
Exercise Dampens Brain Inflammation via Clusterin
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 1868 Views
-
Last post by frodo
-
- 0 Replies
- 2290 Views
-
Last post by frodo
-
- 0 Replies
- 761 Views
-
Last post by NHE
-
- 6 Replies
- 1648 Views
-
Last post by DIM
-
- 2 Replies
- 2956 Views
-
Last post by frodo
-
- 0 Replies
- 1185 Views
-
Last post by frodo
-
- 0 Replies
- 1257 Views
-
Last post by frodo
-
- 0 Replies
- 1305 Views
-
Last post by jimmylegs
-
- 2 Replies
- 1989 Views
-
Last post by NHE