This regimen includes selegiline (l-deprenyl), which is a prescribed medication. I take selegiline at a low daily dose of 5mg. The claims about reducing excitotoxic damage (I understand this as microglia inflammation) and iron-induced memory impairment caught my eye, from this link at The Good Drug Guide (selegiline.com):
Note: I stopped taking selegiline after one month because of side effects. See later posts for more information.
Edit-08042011: Stopped LDN again.Selegiline has immune-system-boosting and anti-neurodegenerative effects. Its use increases the level of tyrosine hydroxylase, growth hormone, cerebral nitric oxide and the production of key interleukins. Selegiline offers protection against DNA damage and oxidative stress by hydroxyl and peroxyl radical trapping; and against excitotoxic damage from glutamate. In addition, selegiline stimulates the release of superoxide dismutase (SOD). SOD is a key enzyme which helps to quench the production of damaging free-radicals. Potentially, selegiline may prevent or reverse iron-induced memory impairment. The deposition of excess iron in the brain is implicated several neurodegenerative diseases.
Edit-06282011: I give up. 2.0mg LDN nightly from now on, I can't live with the increased bladder dysfunction I get with 2.5mg and higher, even if it will go away in 6-9 months. Also, added 1-siberian ginseng capsule at lunch.
Edit-06112011: Adjusted vinpocetine to 10mg twice daily.
Edit-06082011: Start 2.5mg LDN last night, to stop morning headaches.
Edit-06012011: 500mg N-Acetyl Glucosamine (NAG) 3 times daily.
Edit-05312011: Began 3.0mg LDN last night, up from 2.0mg.
Edit-05182011: Vinpocetine 3 times daily to reduce bladder spasticity.
Edit-04222011: Start 1g Lion's Mane Mycelium twice daily.
Edit-04212001: Start 2.0mg LDN nightly at bedtime.
Edit-04202011: Remove 0.25mg rasagiline.
Edit-04072011: Switch from 5mg selegeline to 0.25mg rasagiline
Edit-04072011: Add DLPA (500mg) before lunch
Edit-04042011: EGCG to slow breakdown of noradrenaline?
Edit-04012011: Add B-Vitamins and P5P
Pre-Breakfast (empty stomach)
------------------------------------
600mg N-Acetyl Cysteine
500mg N-Acetyl Glucosamine
1-Bromelain (500mg)
Baby Aspirin (for IJV stents)
300mg Alpha-Lipoic Acid
400mg SAM-E
Breakfast
-----------
Acidophilus
2-calcium (400mg)
1g Lion's Mane Mycelium
100mg phosphatidylserine
10mg Vinpocetine
1-CoEnzyme B Food Complex Vitamin
30mg OptiZinc (Zinc Monomethionine)
50mg P5P
2000IU Vitamin D3
450mg DHA
Pre-Lunch (Empty Stomach)
--------------------------------
500mg N-Acetyl Glucosamine
1-Bromelain (500mg)
1-DLPA (500mg)
Lunch
-------
Acidophilus
2-calcium (400mg)
2000IU Vitamin D
1-250mg Siberian Eleuthero Root Capsule (50:1 potency)
450mg DHA
400IU Vitamin E
Multi-Vitamin
Pre-Dinner (Empty Stomach)
---------------------------------
500mg N-Acetyl Glucosamine
1-Bromelain (500mg)
300mg Alpha-Lipoic Acid
Copaxone injection
6PM
----
480mg - 600mg Verapamil (prescribed for migraine prevention)
Dinner
-------
2-Acidophilus
2-Calcium (400mg)
1g Lion's Mane Mycelium
1-CoEnzyme B Food Complex Vitamin
10mg Vinpocetine
450mg DHA
Bedtime
---------
0 mg Low Dose Naltrexone
When I meet with her again in a few weeks, I'll make the determination of whether to continue with selegiline (based on how I've adjusted to side-effects by then), and will ask for her opinion of starting a tetracycline such as minocycline or doxycycline. There was a recent report of a benefit of combing minocycline with Copaxone:
Minocycline as Add-on Therapy to Copaxone
I also want to ask her advice about the recent reports that show a reduction in the levels of the neurotransmitter noradrenaline with MS:
Noradrenaline Reduction in Multiple Sclerosis
Is there anything in addition to B-Vitamins, Magnesium, and P5P I should consider taking to boost the level of noradrenaline? I have read that DLPA increases production of noradrenaline and EGCG (catechins) inhibit their breakdown.
--Tracy