Re: Beyond Avonex and Valtrex
Posted: Thu Aug 20, 2015 4:04 am
Hi,
Actually, I lie. There is a significant change in my soleus in two days which makes left calf feel completely different. It's a sense of stretch when I walk and it's particularly noticeable going downstairs. Walking has already taken on a different gait and the process of altering my stride is making me acutely aware how much I had favoured my right leg.
The advice was to use the left leg a lot to encourage the muscles to stretch and its more work than I thought it would be.
At the end of the day I feel like I have been in a rugged football game. Not wrecked but definitely sore as muscles begin to respond differently. I'm sure this is transitory and necessary to regain a more normal leg action all round.
I found the leg stretches in Pilates much easier with better range but it's a learning curve to improve the technique. The Baclofen influence on muscles will also be altered as the neurons keep dying off over the week. Both treatments will influence the amount of calcium released by the sarcoplasmic reticulum; The baclofen as a Potassium channel blocker will impede sodium entry into the cell which in turn will slow calcium release and the neuron die off prevents the release of acetylcholine, which triggers the calcium release.
Its very clear that this temporary solution can be a long term answer provide I take the opportunity to lengthen the contracted muscles.
Regards
Actually, I lie. There is a significant change in my soleus in two days which makes left calf feel completely different. It's a sense of stretch when I walk and it's particularly noticeable going downstairs. Walking has already taken on a different gait and the process of altering my stride is making me acutely aware how much I had favoured my right leg.
The advice was to use the left leg a lot to encourage the muscles to stretch and its more work than I thought it would be.
At the end of the day I feel like I have been in a rugged football game. Not wrecked but definitely sore as muscles begin to respond differently. I'm sure this is transitory and necessary to regain a more normal leg action all round.
I found the leg stretches in Pilates much easier with better range but it's a learning curve to improve the technique. The Baclofen influence on muscles will also be altered as the neurons keep dying off over the week. Both treatments will influence the amount of calcium released by the sarcoplasmic reticulum; The baclofen as a Potassium channel blocker will impede sodium entry into the cell which in turn will slow calcium release and the neuron die off prevents the release of acetylcholine, which triggers the calcium release.
Its very clear that this temporary solution can be a long term answer provide I take the opportunity to lengthen the contracted muscles.
Regards