cladribine / leustatin / mavenclad
Posted: Thu Oct 18, 2018 8:48 am
ok so i have this new-to-me neuro i've just seen for the second time. she's making the best attempt to date, of convincing me to consider a dmd.
for the first time since rejecting rebif at dx in 06, i am actually paying attention to the literature on a couple of pharma treatment options.
this is not to say i will go ahead, but my reading has been taking a somewhat unusual direction.
so far, i've been looking at ocrevus / ocrelizumab, its mechanism of action, and whether anything else more 'me' has the potential to have the same effect. and me being me, i've landed on papers like this:
Illuminating vitamin D effects on B cells – the multiple sclerosis perspective (2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754614/
but still have more reading to do.
i have not yet read up on cladribine / mavenclad but it sounds like another b-cell targeter. the early appeal for that one is the sound of the regimen:
year 1 week 1: pill a day for 5 days, year 1 week 5: pill a day for 5 days. done for year 1.
it's a chemo drug mind you - not as keen on the idea of losing hair but it sounds like a thinning thing, not full on.
i asked about cost to me, costs to the health care system, and the doc said a. don't worry about the health care system and b. for now the company *may* still be offering compassionate rates/freebies to get people on it, and if so then eventually that option will dry up.
i hate the commerce of disease management, and i still lean strongly away from pharma, but think i will at least continue with the lit review.
for the first time since rejecting rebif at dx in 06, i am actually paying attention to the literature on a couple of pharma treatment options.
this is not to say i will go ahead, but my reading has been taking a somewhat unusual direction.
so far, i've been looking at ocrevus / ocrelizumab, its mechanism of action, and whether anything else more 'me' has the potential to have the same effect. and me being me, i've landed on papers like this:
Illuminating vitamin D effects on B cells – the multiple sclerosis perspective (2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754614/
but still have more reading to do.
i have not yet read up on cladribine / mavenclad but it sounds like another b-cell targeter. the early appeal for that one is the sound of the regimen:
year 1 week 1: pill a day for 5 days, year 1 week 5: pill a day for 5 days. done for year 1.
it's a chemo drug mind you - not as keen on the idea of losing hair but it sounds like a thinning thing, not full on.
i asked about cost to me, costs to the health care system, and the doc said a. don't worry about the health care system and b. for now the company *may* still be offering compassionate rates/freebies to get people on it, and if so then eventually that option will dry up.
i hate the commerce of disease management, and i still lean strongly away from pharma, but think i will at least continue with the lit review.