uric acid

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jimmylegs
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Re: uric acid

Post by jimmylegs » Sat Nov 25, 2017 12:45 pm

Low serum uric acid levels in patients with acute central nervous system viral infections
http://journals.lww.com/neuroreport/Abs ... te.11.aspx

'Most acute central nervous system (CNS) viral infections lead to either encephalitis or meningitis. Many neurotropic viruses may cause CNS dysfunctions through various mechanisms including oxidative stress. Serum uric acid (SUA) levels, which are associated with oxidative stress and antioxidant status, are reduced in patients with various neurological disorders, including multiple sclerosis. We investigated the possible correlation between SUA levels and clinical disease status in patients with acute CNS viral infections. We measured SUA concentrations in 336 individuals, including 179 healthy individuals and 157 patients with acute CNS viral infections. We found that the patients had lower SUA levels than the healthy individuals did irrespective of sex. Effective therapy significantly increased SUA levels. The patients’ SUA levels were correlated inversely with outcomes as measured with the Glasgow Outcome Scale. SUA levels may be a biomarker for predicting treatment outcomes and prognoses for patients with acute CNS viral infections with inflammatory components.

"In our hospital, the normal SUA range is 208–428 mM for men and 155–357 mM for women...

"... we observed significantly lower SUA levels in patients who had neurological abnormalities (P=0.001), seizures (P=0.006), abnormal EEG results (P<0.001), abnormal MRI findings (P<0.001), or a need for ICU treatment (P<0.001) than in patients who did not have these conditions (Table 4).

.......................................ua in cases with............ua in controls
Neurological abnormalities..181 +/- 82...................225 +/- 69
Cognitive dysfunction.........188 +/- 82...................208 +/- 77

.......................................ua before treatment......ua.after
viral meningitis...................223 +/- 57.................285 +/- 78
viral encephalitis.................205 +/- 96.................261 +/- 100

"SUA levels were evidently decreased in patients with viral CNS infections, but effective treatments restored them. More importantly, lower SUA levels may be related to several phenomena indicative of disease severity, including neurological abnormalities, seizures, abnormal EEG results, abnormal MRI findings, and a need for ICU treatment. Furthermore, lower SUA levels were correlated closely with poor prognoses. Therefore, SUA levels may be a useful biomarker of acute CNS viral infections with inflammatory components and may be useful indicators for prognoses and treatment outcomes."

very interesting. i'd like to have seen a serum zinc test somewhere in this mix.

reference range locally is 140-360. i remember years ago the first time i heard about ua being low in ms (on this forum, btw), had it tested and when it came back 194 i was like "meh, guess ua is fine in MY case" <- jimmylegs, right before figuring out 'normal range' bs
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Re: uric acid

Post by jimmylegs » Sat Nov 25, 2017 1:22 pm

grr info on low ua status in ms deleted on the uric acid wikipedia page. looks like death by a thousand cuts -whittled and whittled until the last piece left was meaningless. needs an updated lit review because there is no way that info should be just *gone*.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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Re: uric acid

Post by jimmylegs » Tue Jul 03, 2018 8:20 am

a slightly different spin on an ms known:

Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients (2018).
https://www.ncbi.nlm.nih.gov/pubmed/29651206

Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression.


yeah i wouldn't expect an ms patient to be excreting much uric acid in urine, when we aren't successfully making the stuff to match serum levels seen healthy controls in the first place.

while i know next to nothing about urine testing, in my opinion more research to clarify interactions between serum uric acid, serum zinc and serum ammonia in MS.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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Re: uric acid

Post by jimmylegs » Mon Aug 27, 2018 3:37 pm

ran across this one in passing, while hunting for something else. completely weird-looking uric acid results for ms patients.

Serum Metabolic Profile in Multiple Sclerosis Patients (2011)
https://bit.ly/2BRMf2H

.................Controls (n = 163).....MS patients (n = 170)
Uric acid.......258.08 ± 50.39........299.88 ± 70.17a

mine was stuck around 190 for ages. was ecstatic to finally get the level UP to 278.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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jimmylegs
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2006: zinc copper and uric acid in hemodialysis patients

Post by jimmylegs » Sun Feb 10, 2019 5:41 am

  • Longitudinal study of serum zinc and copper levels in hemodialysis patients and their relation to biochemical markers (2006)
    https://link.springer.com/article/10.13 ... :113:3:209

    Mean serum zinc and copper concentrations in HPs were significantly decreased (Zn) and increased (Cu), when compared with healthy controls (p<0.01). ... Uric acid and parathyroid hormone ... were significantly (p<0.05) and linearly related with serum zinc ... concentrations.
maybe at some point we'll get research looking at zinc and uric acid status in ms. maybe even treatment effects of oral zinc, too.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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