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NHE
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by NHE » Tue Aug 13, 2019 3:36 am
High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial
The Journal of Nutrition, Volume 148, Issue 8, August 2018, Pages 1380–1386
- Background: Combined omega-3 fatty acid and vitamin D supplementation may improve multiple sclerosis (MS) by correcting metabolic abnormalities and attenuating oxidative stress and inflammation.
Objective: This study aimed to determine the effects of ω-3 fatty acid and vitamin D cosupplementation on the disability score and metabolic status of patients with MS.
Methods: This was a randomized, placebo-controlled clinical trial with Expanded Disability Status Scale (EDSS) score and inflammation as primary outcomes and oxidative stress biomarkers and metabolic profile as secondary outcomes. Patients, aged 18–55 y, were matched for disease EDSS scores, gender, medications, BMI, and age (n = 53) and randomly received a combined 2 × 1000 mg/d ω-3 fatty acid and 50,000 IU/biweekly cholecalciferol supplement or placebo for 12 wk. The placebos were matched in colour, shape, size, packaging, smell, and taste with supplements. Fasting blood samples were collected at baseline and end of intervention to measure different outcomes. Multiple linear regression models were used to assess treatment effects on outcomes adjusting for confounding variables.
Results: Patients taking ω-3 fatty acid plus vitamin D supplements showed a significant improvement in EDSS (β −0.18; 95% CI: −0.33, −0.04; P = 0.01), compared with placebo. Serum high-sensitivity C-reactive protein (β −1.70 mg/L; 95% CI: −2.49, −0.90 mg/L; P < 0.001), plasma total antioxidant capacity (β +55.4 mmol/L; 95% CI: 9.2, 101.6 mmol/L; P = 0.02), total glutathione (β +51.14 µmol/L; 95% CI: 14.42, 87.87 µmol/L; P = 0.007), and malondialdehyde concentrations (β −0.86 µmol/L; 95% CI: −1.10, −0.63 µmol/L; P < 0.001) were significantly improved in the supplemented group compared with the placebo group. In addition, ω-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations.
Conclusion: Overall, taking ω-3 fatty acid and vitamin D supplements for 12 wk by patients with MS had beneficial effects on EDSS and metabolic status. This trial was registered at the Iranian website (www.irct.ir) for registration of clinical trials as IRCT2017090133941N20.
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Zyklon
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by Zyklon » Tue Aug 13, 2019 8:56 am
And we still have doctors saying that "no proven benefits blablabla"...
Pain! You made me a, you made me a believer, believer
Pain! You break me down, you build me up, believer, believer
Pain! Oh let the bullets fly, oh let them rain
My life, my love, my drive, it came from... Pain!
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Last post by NHE
Thu Aug 29, 2019 11:27 pm
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Treating Disease with EFAs/Omega-3
Replies: 1
First post
EFAs (Essential Fatty Acids) are called essential because they have been deemed necessary for good health. These EFAs must be consumed and cannot be...
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For a lot of additional reading (over 2 million results), do a Google search for
treatment of disease with omega 3
or
treatment of disease with...
- 1 Replies
- 858 Views
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Last post by ElliotB
Mon Apr 30, 2018 3:12 am
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Vitamin E for MS
Replies: 2
First post
We already knew about vitamin D, but it seems vitE could also delay MS progression.
Vitamin E administration erases an enhanced oxidation in...
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vitamin e, and alpha tocopherol in particular, features prominently in the klenner protocol. when this protocol did me so much good in 2006 i was...
- 2 Replies
- 573 Views
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Last post by jimmylegs
Fri Aug 17, 2018 3:39 am
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'vitamin O'
Replies: 1
First post
Oxygen Is Good, Even When It’s Not There
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I have been doing oxygen therapy/EWOT Therapy for several years using a very inexpensive home oxygen concentrator. Don't know if it helps but I know...
- 1 Replies
- 1528 Views
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Last post by ElliotB
Tue Dec 12, 2017 4:23 am
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Vitamin K
2018 Aug 27
Department of Biological Sciences, Geauga campus, Kent State University, Burton, Ohio
Vitamin K enhances the production of brain...
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- 593 Views
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Last post by Petr75
Thu Sep 13, 2018 8:23 am
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Vitamin D for MS
Replies: 1
First post
VitD in MS. review
Chapter 8 - The Way Forward With Vitamin D in Multiple Sclerosis
Abstract
Vitamin D exposure has gained interest as a...
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related TiMS info here
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- 640 Views
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Last post by jimmylegs
Fri Aug 17, 2018 3:46 am
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Vitamin D: Dysequilibrium in MS
Replies: 2
First post
Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study
Background
Parathyroid glands...
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would have been nice if they bothered to give any detail on the form of magnesium used. also, i'd have loved to see what happened to vit D...
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Last post by frodo
Sun Jun 03, 2018 11:20 pm
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How safe is vitamin D?
Replies: 5
First post
How safe is vitamin D?
Posted on: December 18, 2017 by John Cannell, MD
“All things are toxic, and nothing is without toxicity; the dose alone...
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Yesterday my brother went to the Coimbra Protocol doctor.
He looked at his tests 25(OH)D3, PTH, Calcium (total and ionized), Urea & creatinine,...
- 5 Replies
- 2608 Views
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Last post by AntonioBR
Wed Jul 18, 2018 3:17 pm
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Vitamin K probably should be taken with higher doses of D3
Replies: 9
First post
Vitamin K, among other things, is thought to balance calcium in your arteries. Since those on high doses of vitamin D3 are warned to limit calcium in...
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Just thought I would add. Michael Cawley said it has to be 200mcg to work. That was the amount used by his patients. In the Menoquin Gold ad. above,...
- 9 Replies
- 1737 Views
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Last post by Kittie
Wed May 15, 2019 11:57 pm