item 1: some vit D is good; item 2: a lot may be toxic
Correlation between vitamin D and alterations in MRI among patients with multiple sclerosis (2021)
"... high serum levels of vitamin D, in this case 75 nmol/Lor higher (p=0.021) and 100 nmol/L or higher (p=0.016), were associated with lower levels of NfL in cerebrospinal fluid. NfL levels also correlated with the number of contrast-enhancing brain lesions on MRI (p<0.0005) .
patients with MS featured significantly lower vitamin D levels than healthy volunteers (15.9 nmol/L vs. 20.6 nmol/L; p<0.0001).
Serum concentrations below 50 nmol/L indicated higher risk of MS occurrence (p=0.024) and an increased likelihood of disease progression (p<0.001) .
In addition, little difference in EDSS score was observed between 2 groups of MS patients receiving either 20,400 IU or 400 IU over a period of 18 months (p=0.64), suggesting that vitamin D in excess doses does not have a differential impact on MS progression"
so modest d3 levels may be protective, and can be achievable with modest daily d3 intakes - provided of course that suitable cofactors are in the mix (doesn't seem to be any mention of such in this article, mind you). interesting:
Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine
"... What has largely been forgotten, however, is that higher levels of 25(OH)D3 have been linked to enhanced absorption of toxic elements such as aluminum, cadmium, cobalt, and lead as well as radioactive isotopes including cesium and radioactive strontium .
It is important to recognize that vitamin D does not work alone but requires essential minerals to achieve its full benefit. Deficiency of minerals including magnesium, calcium, zinc, and iron is very common as outlined above. Recognizing the synergistic action of mineral deficiency with elevated vitamin D levels on the uptake of toxic elements, adequate intake of minerals needs to be ensured."
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