d3 magnesium epigenetics, interactions
https://www.sciencedirect.com/science/a ... 2817304782
• Low Vitamin D levels are associated with MS susceptibility and –progression.
• UVB light is involved in MS etiology and progression independent from Vitamin D.
• Clinical aspects of UVB light and Vitamin D in epidemiological and clinical studies.
• α-MSH as an environmental mimetic for the development of novel MS therapeutics.
"Interestingly, genetic variation in Vit D binding protein (SNP rs4588 or its proxy rs2282679) has further been found to result in a smaller serum Vit D increase after vitamin D3 supplementation as compared to individuals without the SNP (Nimitphong et al., 2013), demonstrating some pharmacokinetic implications in potential supplementation regimens. In this line, the responsiveness to Vit D supplementation seems to also be impaired in MS patients: a recent study investigating whether Vit D supplementation results in similar increase in serum Vit D levels in healthy controls and MS patients showed that people with MS had a lower increase in Vit D levels following oral vitamin D supplementation as compared to healthy controls (Bhargava et al., 2016). These findings might support assumptions that are the basis of the so-called “Coimbra protocol” claiming that MS patients (and other autoimmune diseases) need higher doses of Vit D to reach adequate levels due to a genetically caused hypovitaminosis D (Finamor et al., 2013). As there are no peer reviewed study results available for the effects of the “Coimbra protocol” (doses of Vit D up to 400.000 IU!), it is currently unclear if ultrahigh doses of Vit D really have the desired disease-modifying effect, nor if the higher risk of side effects from ultra-high doses is worth the benefit"
oh genetics, you say? and what might fire up SNP rs4588, i wonder??
Therapeutic perspectives of epigenetically active nutrients (2015)
"So far, only magnesium has been linked to epigenetics (Takaya et al., 2011)."
all right we'll wait and see. in the meantime, recalling this one posted a year ago and recently revisited above:
Role of Magnesium in Vitamin D Activation and Function (2018)
"Vitamin D is transported in blood bound to the carrier proteins, and the major carrier is vitamin D–binding protein. Importantly, the activity of vitamin D–binding protein is also a magnesium-dependent process (Figure 2).62,63"
test day tomorrow - doing d3 and mag together, followed by any corrective action that may be needed, then a retest. can somebody please arrange to scale this solo effort up...!?!