all things vitamin D

1hunter · Post by **1hunter** » Fri Feb 18, 2011 3:26 pm

Thanks Jimmy
that is good to know, are there others that should or shouldn't be mixed? I thought i read we should take fish oil with vit. D But not calcium with with fish oil.

CVfactor · Post by **CVfactor** » Fri Feb 18, 2011 4:47 pm

The review article below is probably the best that I have found that explains the regulatory T-cell function in a easy to understand way:

http://www.nature.com/nrneurol/journal/ ... o0832.html

Post by **jimmylegs** » Fri Feb 18, 2011 6:33 pm

hey there no probs. i had not heard pros or cons about fish oil timing/combinations, but i do know that magnesium and calcium compete with each other for absorption so that's a combo to avoid in the same pill OR make sure the ratio of ca to mag is right for you, depending on your problem eg spasticity vs weakness or whatever.

CVfactor · Post by **CVfactor** » Wed Feb 23, 2011 4:52 pm

Here is another article on Treg cell dysfunction using monkeys as opposed to mice as test subjects:

http://www.ncbi.nlm.nih.gov/pubmed/19539557

CVfactor · Post by **CVfactor** » Sun Feb 27, 2011 4:46 pm

Here is a paper that describes the concept of molecular mimicry:

http://www.ncbi.nlm.nih.gov/pubmed/19303388

For those that are not familiar, it is in essence the fact that certain pathogen peptides have a remarkably similar structure to that of myelin basic protein.

This is one explanation of why people with MS that have a dysfunctional immune system (in particular Tregs) have a propensity to attack the myelin sheath on their neural axons.

CVfactor · Post by **CVfactor** » Mon Feb 28, 2011 6:04 pm

Here is an article on the discovery of Tr1 regulatory cells:

http://www.ncbi.nlm.nih.gov/pubmed/16464609

and another article:

http://www.jci.org/articles/view/23395/pdf

and another:

http://onlinelibrary.wiley.com/doi/10.1 ... 2/abstract

and another:

http://www.ncbi.nlm.nih.gov/pubmed/17936368

jackD · Post by **jackD** » Tue Mar 01, 2011 12:18 am

One of the nice things about Vitamin D3 is that it is "a potent producer of NGF -Nerve Growth Factor".

This stuff is really GREAT for those small MS brain repair jobs.

Warning !!!! Warning!!! Warning!!!

ONLY THE TRUELY PREVERTED should visit this Web Site!!@!

http://www.copewithcytokines.de/cope.cgi?key=NGF

jackD

MSUK · Post by **MSUK** » Fri Mar 04, 2011 6:25 am

New research into the neurodegenerative disease, Multiple Sclerosis (MS) offers new insight into the link between sunlight, vitamin D3, and MS risk and severity. The research, published in the European Journal of Immunology, studies the relationship between the sunlight-dependent vitamin D3 hormone, immune cells, and the risk and severity of autoimmunity in an experimental model.

Expensive first-line treatments for MS modestly reduce the frequency of autoimmune attacks but do not slow disease progression, when the patient's immune system operates against the body's own tissues. More expensive second-line treatments slow disease progression but carry high risks. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1334

Apuman · Post by **Apuman** » Fri Mar 04, 2011 3:39 pm

Thanks for sharing this info. It seems to me that if there's one thing that we can put our money on with MS, it's that vitamin D plays a crucial role. The last two doctors I saw were worlds apart with thier ideas... One was a neuro who told me he wanted me on CRABS asap, the other was an MD who also practices eastern medicine. What was the one thing that they both told me was important? You guessed it...

Wonderfulworld · Post by **Wonderfulworld** » Sat Mar 05, 2011 4:01 am

Thanks great to see that VitaminD3 can help those of us who have already got MS, not just pre-diagnosis. Thanks for posting this!

Leonard · Post by **Leonard** » Sat Mar 05, 2011 9:59 am

I invite you to have a look at this thread
http://www.thisisms.com/ftopict-15188.html
my posting from 30 Jan 6:11am

quote: the relation of MS and Vitamin D is well known. High Vitamin D during the time your mother was pregnant from you and your youth (in the period your cells were growing) reduces the risk for MS. The intra-cellular calcium will be lower if there was a high Vitamin D level; conversely, the intra-cellular calcium will be elevated if there was a lack of Vitamin D. Sustained elevations of intracellular calcium may inhibit insulin-target cells from sensing the brisk intracellular calcium fluxes necessary for insulin action, such as in particular glucose transport. See this recent article in the International Journal of Endocrinology:
http://www.hindawi.com/journals/ije/2010/351385.html

I believe that here is the real explanation for the Vit D relationship.
Whether additional Vit D later on helps or not is less clear: I have seen reports to both sides. It seems Vit D does have an immuno-modulating effect.

Post by **jimmylegs** » Sat Mar 05, 2011 10:17 am

in the early days when i was trying to decide if i'd take rebif or not, i found a study that basically said that 1,25 dihydroxycholecalciferol had similar biochemical action to interferon. try as i might i cannot find that study again but i sure wish i could.

Wonderfulworld · Post by **Wonderfulworld** » Sat Mar 05, 2011 10:32 am

JL it's not this is it? http://bloodjournal.hematologylibrary.o ... 06/13/4351 - it's the opposite though, with Interferon Gamma being surpressed by D3....?

Post by **jimmylegs** » Sat Mar 05, 2011 11:11 am

that's pretty close, ww, well done! but not quite the one i remember. maybe if i throw that in pubmed and check out related studies it'll come up.

but yes it's getting at similar stuff, basically this is the kind of info that makes me think of 1,25dihydroxycholecalciferol as part of the immune system's 'brakes'. if you don't have enough 25(OH)D3 you don't have good stores for building 1,25dihydroxycholecalciferol, so if the immune system says 'attack' there's not enough 'stop attacking' messaging going on at the same time.

"macrophages can produce 1,25(OH)2D3 on activation with interferon (IFN-)"

"1,25(OH)2D3 can selectively suppress key effector functions of IFN-–activated macrophages"

"production of 1,25(OH)2D3 by IFN-–stimulated macrophages might be an important negative feedback mechanism to control innate and inflammatory responses of activated macrophages"

Post by **jimmylegs** » Sat Mar 05, 2011 11:23 am

another tidbit..
http://www.ncbi.nlm.nih.gov/pubmed/14718698
"The mechanisms of these favorable effects of vitamin D are not entirely known but could be related to the ability of 1,25(OH)2D3 to inhibit
the production of the Th1-associated cytokines interleukins-12 and 2, interferon-gamma, and tumor necrosis factor-alpha, thus suppressing the development and proliferation of the inflammatory Th1 cells."

full text
http://www.shahomework.com/mathclass/ar ... les/18.pdf

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