all things magnesium

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jimmylegs
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magnesium vasodilation

Post by jimmylegs » Mon Sep 02, 2019 6:48 am

Mechanisms responsible for vasodilation upon magnesium infusion in vivo: clinical evidence. (2002) https://www.ncbi.nlm.nih.gov/pubmed/12635879

A number of studies have shown that intravenous administration of magnesium (Mg) is an effective treatment for acute coronary syndromes. While mechanisms such as antiarrhythmic, antithrombotic, and myocardial cytoprotective effects may be involved, a vasodilatory effect is among the likely beneficial effects of Mg infusion. The vasodilatory effect of Mg is incompletely understood. On one hand, Mg can act as a physiologic calcium-antagonist, but in addition interest recently has been focused on whether endothelium-derived nitric oxide is involved in Mg-induced vasodilation. Another issue in Mg-induced vasodilation is whether the specific Mg salt administered influence the degree of vasodilation. Although Mg sulphate has undergone more clinical studies than Mg chloride, experimental studies suggest that Mg chloride influences vasculature more than Mg sulphate. No clinical research has investigated whether the vasodilatory effect of Mg differs according to the associated anion administered. The present review includes evidence concerning mechanisms of the vasodilatory effect of Mg including endothelium-derived nitric oxide, as well as the possible differences between different Mg salts.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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jimmylegs
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Joined: Sat Mar 11, 2006 3:00 pm

CSF Mg & vasodilation

Post by jimmylegs » Mon Sep 02, 2019 8:54 am

Optimal cerebrospinal fluid magnesium ion concentration for vasodilatory effect and duration after intracisternal injection of magnesium sulfate solution in a canine subarachnoid hemorrhage model (2015)
https://www.ncbi.nlm.nih.gov/pubmed/21073257

Object
The optimal CSF Mg++ concentration for vasodilation of spastic cerebral arteries after subarachnoid hemorrhage (SAH) and its duration are unknown. The temporal profile of the vasodilatory effect and optimal CSF Mg++ concentration after the intracisternal injection of MgSO4 solution were investigated in an SAH model in canines.

Methods
Cerebral vasospasm was induced by experimental SAH using a 2-hemorrhage model in 26 female beagles. On Day 7, 0.5 ml/kg of 15, 10, 5, or 0 mmol/L MgSO4 in Ringer solution was injected into the cerebellomedullary cistern. Angiography was performed on Day 1 (before SAH) and before and 1, 3, and 6 hours after the intracisternal injection on Day 7 to measure arterial diameters of the basilar artery (BA), superior cerebellar artery (SCA), and vertebral artery (VA). Cerebrospinal fluid Mg++ was also measured at the same time.

...

Conclusions
The reversible effect of an intracisternal injection of MgSO4 solution on the spastic artery requires CSF Mg++ concentrations > 3 mEq/L. The vasodilatory effect continues for 3–6 hours after injection. These results suggest that the continuous infusion or intermittent intracisternal injection of MgSO4 is needed to maintain the optimal CSF Mg++ concentration and constantly ameliorate cerebral vasospasm.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

THX1138
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Posts: 725
Joined: Tue May 14, 2013 2:00 pm

Re: all things magnesium

Post by THX1138 » Wed Sep 04, 2019 12:13 pm

Great find !
Maybe this is why my head cools and becomes way less full feeling after I do an Mg treatment (with Mg oil).

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