all things magnesium

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NHE
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Re: all things magnesium

Post by NHE » Sun Oct 06, 2013 10:39 pm

dez2000 wrote:After 2.5 hours research, silica was never mentioned.
Sure it was. It was right in your post...
dez2000 wrote:Search 'diatomaceous earth testimonials’ Hundreds of people have recorded the effects of their experiences with ‘DE’ most are amazed at what the 'dirt' has done for them, friends and family. I recommend taking DE with at least vitamin C for ‘C’ with silica makes up the cell walls of our body.
Animal cells don't have cell walls.

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jimmylegs
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Re: all things magnesium

Post by jimmylegs » Mon Oct 07, 2013 3:16 am

I put "diatomaceous earth" in google scholar. can't find any research on benefits other than as insecticide, or as a filter component. tried "diatomaceous earth" health. all the research appears to be on inhalation risks.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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Re: all things magnesium

Post by dez2000 » Mon Oct 07, 2013 12:50 pm

all things magnesium

I have read the many post on magnesium posted here. A lot of them contain very good scientific and accurate information. Healthy people with healthy nutritious diets get enough magnesium for there needs.

People on low calorie diets, have health issues and diseases and are under stress to often not. Where I have problem is that many of the post here, refer to the FDA’s, and its RDA.

I went to Doctor Linus Pauling, Americas primer Scientist and two time Nobel Prize winner. His research papers on vitamins and nutrients are thorough and in depth. His papers on magnesium are no less. dez

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magnesium dysphagia

Post by jimmylegs » Sun Oct 20, 2013 1:49 pm

my dysphagia was related to chronic magnesium depletion. i didn't know i had been low for years previously (most people are). i learned about the importance of minerals after diagnosis and started taking some magnesium, but then i made things worse by taking vitamin d3 at higher doses and not balancing or timing my magnesium supplement correctly. the dysphagia was the single scariest symptom of all the different symptoms i have experienced. at its worst it was combined with an inability to draw a complete full breath. the things we take for granted! anyway. at one time my magnesium status was so bad that i could take a magnesium pill (well away from any vitamin d3) and within an hour i would feel a physical reaction like a shock or knock in my throat when the biochemistry would kick into gear. i am not 100% sure of the number, but the worst magnesium test result i have on file was 0.88 mmol/L. that is well within the 'normal' range and no doctor would have said that magnesium was my problem. i was just lucky to run into a smart pharmacist one day who told me what i was doing wrong and set me on the correct track.

if you are symptomatic for magnesium deficiency (muscle stiffness is typical) you can do several things:
-verify your levels with a serum magnesium test (it will be 'normal' but deficiency symptoms are known to occur inside the normal range - aim for very high normal ie 1.1 mmol/L)
-increase daily intake to 600mg per day (not the easiest thing with diet alone)
-eat LOTS of nutrient dense magnesium rich foods
-choose a very high quality magnesium supplement (magnesium glycinate is a smart choice for best absorption - cheap forms just go right through you and are not retained in any useful way)
-drink mineral water
-avoid coffee, alcohol, dark coloured carbonated beverages (phosphorus)
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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Re: all things magnesium

Post by THX1138 » Sun Nov 17, 2013 7:21 pm

Healthy people with healthy nutritious diets get enough magnesium for there needs.
1) Most people do not have healthy, nutritious diets.
2) The RDA's are meant for Healthy People with No Deficiencies.

3) As a Doctor once told me, people with ms are magnesium wasters and thus, need far more magnesium.

Regarding the most common way of testing magnesium levels, here is a study of peer reviewed articles entitled, The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for "normal" results.
http://www.ncbi.nlm.nih.gov/pubmed/20170394


THX1138

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Re: all things magnesium

Post by THX1138 » Mon Dec 02, 2013 8:45 pm

The multifaceted and widespread pathology of magnesium deficiency.
The range of pathologies associated with Mg deficiency is staggering: hypertension (cardiovascular disease, kidney and liver damage, etc.), peroxynitrite damage (migraine, multiple sclerosis...
http://www.ncbi.nlm.nih.gov/pubmed/11425281

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Last edited by THX1138 on Tue Apr 29, 2014 2:40 pm, edited 2 times in total.

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lyndacarol
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Re: all things magnesium

Post by lyndacarol » Thu Jan 02, 2014 7:22 am

I think this belongs here also:

Dietary Mg is absorbed in the small intestine, the same area affected by gluten in those with celiac disease.

And from a 1968 article! Almost 40 years old!… I can't believe they are still charging for this!

Magnesium Metabolism, a study published in The New England Journal Of Medicine, March 28, 1968 (http://www.nejm.org/doi/pdf/10.1056/NEJM196803282781306) found a "striking magnesium loss" in the stools of those with untreated celiac disease—up to four times as high as dietary Mg intake. That same study found that "this remarkable loss was reversed by the institution of a gluten-free diet."

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Re: all things magnesium

Post by lyndacarol » Thu Jan 02, 2014 2:38 pm

I found the following interesting, since I have had no appetite for YEARS and now have tingling, muscle contractions and cramps; thought others might find this information interesting, too:

http://ods.od.nih.gov/factsheets/Magnes ... fessional/
Magnesium Deficiency
Symptomatic magnesium deficiency due to low dietary intake in otherwise-healthy people is uncommon because the kidneys limit urinary excretion of this mineral [3]. However, habitually low intakes or excessive losses of magnesium due to certain health conditions, chronic alcoholism, and/or the use of certain medications can lead to magnesium deficiency.
Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur [1,2]. Severe magnesium deficiency can result in hypocalcemia or hypokalemia (low serum calcium or potassium levels, respectively) because mineral homeostasis is disrupted [2].

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lyndacarol
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Re: all things magnesium

Post by lyndacarol » Thu Jan 02, 2014 3:10 pm

lyndacarol wrote:I think this belongs here also:

Dietary Mg is absorbed in the small intestine, the same area affected by gluten in those with celiac disease.

And from a 1968 article! Almost 40 years old!… I can't believe they are still charging for this!

Magnesium Metabolism, a study published in the New England Journal Of Medicine, March 28, 1968 (http://www.nejm.org/doi/pdf/10.1056/NEJM196803282781306) found a "striking magnesium loss" in the stools of those with untreated celiac disease—up to four times as high as dietary Mg intake. That same study found that "this remarkable loss was reversed by the institution of a gluten-free diet."
Someone inquired about the link above and the minimal introduction to the study. I have obtained a printed copy of the article from the nearby College of Medicine library, but do not have access to the actual PDF file (scanner is not available). The information above appears in a paragraph on page 713,
Studies of magnesium balance in celiac disease revealed a striking magnesium loss in the stools: as high as four times the dietary intake.⁽¹°°⁾ This remarkable loss was reversed by the institution of a gluten-free diet.

100. Goldman, A.S., VanFossen, D.D., and Baird, E.E.Magnesium deficiency celiac disease. Pediatrics 29:948-952, 1962.

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Re: all things magnesium

Post by leonardo » Thu Feb 27, 2014 1:34 pm

http://www.turkishjournalpediatrics.org/?fullTextId=238

Have a look at this study on Mg level in diabetic children.

They do have low Mg levels, serum Mg level is low but in normal range, erythrocyte magnesium is very low.

"So Erythrocyte magnesium measurement is preferred to serum magnesium. In conclusion, erythrocyte magnesium levels decrease earlier than serum magnesium in diabetic children. "

What is interesting, the urine Mg is high although there is a lack of Mg in the body... Why are they wasting it?

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c-reactive protein Re: all things magnesium

Post by jimmylegs » Sun Mar 02, 2014 9:56 am

re inverse correlation between c-reactive protein and magnesium intake
http://www.thisisms.com/forum/natural-a ... ml#p222294

a brief history of c-reactive protein at TiMS

magnesium and crp
http://www.thisisms.com/forum/chronic-c ... tml#p49424

zinc and crp
http://www.thisisms.com/forum/post52967 ... ein#p52967

magnesium and crp
http://www.thisisms.com/forum/post54633 ... ein#p54633

everything but the kitchen sink and crp (mag, vit D, vit A, vit C, vit B6, iron, etc etc etc)
http://www.thisisms.com/forum/general-d ... tml#p55740

stress impacts on crp and trace minerals
http://www.thisisms.com/forum/general-d ... ml#p200639
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

THX1138
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Re: all things magnesium

Post by THX1138 » Mon Mar 24, 2014 7:56 pm

Magnesium in the Central Nervous System

Here is link to the free e-book.
http://www.adelaide.edu.au/press/titles ... -ebook.pdf

It takes a minute or so to load.

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Re: all things magnesium

Post by THX1138 » Thu Apr 24, 2014 6:51 pm

Magnesium in the Central Nervous System

Here is the link to the free e-book.
http://www.adelaide.edu.au/press/titles ... -ebook.pdf

It takes a minute or so to load.
Chapter 9 Magnesium in edema and blood-brain barrier disruption
Abstract
The blood-brain barrier (BBB) is constituted primarily of brain capillary endothelial cells and is a pre-requisite for the maintenance of brain homeostasis that is essential for optimal brain function. However, a variety of pathological conditions, such as sepsis, multiple sclerosis and epilepsia disrupt the BBB integrity and lead to the development of brain edema. Ionized magnesium (Mg2+) is a crucial cofactor that plays an essential role within the cell and regulates a variety of biochemical reactions. Changes in intra- and extracellular Mg2+ concentrations influence the functions of cells and tissues. A growing body of evidence suggests that Mg2+ plays a pivotal role in ameliorating BBB disruption via a number of mechanisms during certain neurological diseases. Systemic delivery of Mg2+ may constitute an alternative approach in the future, both to improve BBB integrity and to decrease brain edema in the course of a variety of diseases involving brain tissue.

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Re: all things magnesium

Post by THX1138 » Tue Apr 29, 2014 11:43 am

jimmylegs wrote:
On the other hand the serum Magnesium was optimal with 1.97mg/dl (range 1.7 to 2.2 mg/dL)
the range your lab is using is FAR from optimal. in fact, particularly bad.

it's known that magnesium deficiency occurs within commonly used normal ranges for serum magnesium, and lower cutoffs of 2.2 to 2.3 mg/dL have been proposed in more than one study.

here are some normal ranges i've seen at my local labs, and on the bloodwork of TiMS members over time:

0.65-1.05 mmol/L (1.6-2.6 mg/dL)
0.70-1.10 mmol/L (1.7-2.7 mg/dL) (this is what my lab uses)
0.70-1.0 mmol/L (1.7-2.4 mg/dL)
0.74-1.0 mmol/L (1.8-2.4 mg/dL)
0.65-1.1 mmol/L (1.6-2.7 mg/dL)

with serum mag you need to be 2.3-2.7 mg/dL.. your low serum mag and low RBC mag are conistent with each other - you still have quite a ways to go.

THX was in a similar situation and we've been having some success through working with magnesium cofactors. do you know what your b6, potassium, and zinc status is like? what are you doing in terms of hydration and fatty acids? we could discuss in a separate topic, perhaps here would be good: http://www.thisisms.com/forum/natural-a ... 68-90.html
see you over there :)
Here are a few more reference ranges for serum Mg:
My local lab: 1.2 - 2.1 mg/dL
Massachusetts General Hospital: Adults: 1.8 mg/dL-3 mg/dL (0.8 mmol/L-1.2 mmol/L)
What are normal results for this test?
Laboratory test results may vary depending on your age, gender, health history, the method used for the test, and many other factors. If your results are different from the results suggested below, this may not mean that you have a disease. Contact your healthcare worker if you have any questions. The following is considered to be a normal result for this test:

Adults: 1.8 mg/dL-3 mg/dL (0.8 mmol/L-1.2 mmol/L) [2]
http://www.muschealth.com/lab/content.aspx?id=150017


I have been told (when I bring up the issue of "normal" ranges) by health care professionals that different labs use different equipment, so the normal ranges vary.
Do these differences in equipment make much difference, or is the difference negligible :?:

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Re: all things magnesium

Post by jimmylegs » Tue Apr 29, 2014 9:10 pm

i think it helps if you try to stick to one machine if you plan to watch trends over time.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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