uric acid

[jimmylegs]

i think when you see ms "and" low b12 it's more likely to just be low b12 than ms!

what initiated the liver enzymes testing?

[DIM]

I do regular blood tests to my wife just in case as she takes many supplements, better safe than sorry!

[Farah]

Hi all

I have recently been diagnosed with RRMS.

I have researched a lot about the benefits of Inosine.
My neurologist is not so keen on the approach though so am unable to obtain a prescription for this.

I am based in the UK, does anyone know where I can get Inosine or who I could see with a view to getting a prescription ?
I'm finding i'm hitting a brick wall each way I turn !
Any help would be much appreciated !

[schnittke]

You can order from iherb without a prescription but it is across the pond
from you. Here is a link.

http://www.iherb.com/ProductDetails.aspx?c=1&pid=1323

[DIM]

Many food supplements sell inosine Farah, usualy the Source Natural 500mg Inosine, but you can also find the Ultimate Nutrition Premium Inosine that is also pure and the cheaper around, unfortunately I can't find a reliable e-shop that sends it here in Greece from USA.
What are your uric acid levels, wife's was on the lower side between normal levels so I'll try to increase it.

[g123]

Is there a big risk of gout? Would that be easily avoided by testing to make sure your levels don't get too high?

[jimmylegs]

ms-ers average around 194, optimal is supposed to be 290 in healthy controls, gout can start as low as 350 or so, but in some patients it can get as high as 565 with no development of gout.
the test is no problem i've had it done four times now, about twice a year.

[g123]

For those of you looking to increase your uric acid levels- what is your goal level? Is it still safely under the level where one would worry about gout? How often do you get tested?

Is it a simple blood test that a GP would prescribe?

[g123]

nevermind, these questions were answered in the other thread.
thanks

[g123]

"average" level is 194. i've had that exact result twice. my third (middle) result was 188.
ms-ers in relapse average in the 160s.
remission is in the neighbourhood of 230ish??? can't remember that remission number exactly.
optimal for healthy controls is 290.
gout range is around 350 and up.

that is fascinating. where are these number (relapse vs. remission levels, ms vs. control levels, etc)?

[DIM]

ms-ers average around 194, optimal is supposed to be 290 in healthy controls, gout can start as low as 350 or so, but in some patients it can get as high as 565 with no development of gout.
the test is no problem i've had it done four times now, about twice a year.

Jimmy where did you find these numbers, I thought optimal is 4 and above while these sites mention it around 5-5.5mg/dL?
http://www.dalesplace.net/lab_values.ph ... %20Enzymes
http://www.bloodbook.com/ranges.html#BLOOD
Are you sure that optimal is so low, my wife's is 2.9mg/dL which is optimal according to what you say but low according to the above sites?

[jimmylegs]

depends on the units DIM, i will find the conversions for you... stand by ;)

[jimmylegs]

okay i was using µmol/L
1mg/dL=59.48 µmol/L
how do your wife's numbers translate into µmol/L

[jimmylegs]

hiyas, i have had all these sources posted to the uric acid page on wikipedia for quite some time now, but for those who don't have access to read source full-text, here are some excerpts:

Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood–brain barrier dysfunction
http://www.blackwell-synergy.com/links/ ... 02.00384.x

MS patients were found to have significantly lower serum uric acid levels (193.89 ± 49.05 µmol/l; mean value ±SD) in comparison with healthy donors (292.7 ± 58.65 µmol/l; P = 0.000) and OIND (jimmy: "other inflammatory neuro disease") patients (242.7 ± 46.66 µmol/l; P = 0.001). We found that MS patients with relapse had significantly lower serum uric acid levels (161.49 ± 23.61 µmol/l) than MS patients with remission (234.39 ± 41.96 µmol/l; P = 0.000) and more over, MS patients with BBB disruption had significantly lower serum uric acid levels (163.95 ± 26.07 µmol/l) than those with normal BBB (252.48 ± 25.94 µmol/l; P = 0.000). Further, we also found that serum uric acid level independently correlated with disease activity, BBB disruption, and gender. These results indicate that lower uric acid levels in MS patients are associated with relapse and suggest that uric acid might be beneficial in the treatment of MS.

Role of uric acid in hypertension, renal disease, and metabolic syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/1719 ... stractPlus

Many patients have hyperuricemia (uric acid > 7.0 mg/dL in men and > 6.5 mg/dL in women) but do not have gout.

Biochemistry of uric acid and its relation to gout.
http://www.ncbi.nlm.nih.gov/pubmed/1398 ... t=Citation
no abstract. findings available here:
http://www.labcorp.com/datasets/labcorp ... 009100.htm

The overlap between uric acid levels in those with and without gout is shown in a study in which the lowest level in a gouty subject was 6 mg/dL, while the highest uric acid in a nongouty person was 9.5 mg/dL.
citation:
Seegmiller JE, Laster L, and Howell RR, “Biochemistry of Uric Acid and its Relation to Gout,” N Engl J Med, 1983, 268:712-6

[jimmylegs]

this is a link to the SI conversion factor table, very useful:
http://www.unc.edu/~rowlett/units/scale ... _data.html

so for uric acid 1mg/dL=59.48 µmol/L

if a person has a level 2.9 mg/dL, that would correlate to ~172 µmol/L, which is worse than my personal (recorded) low of 188 µmol/L.

the 290 optimal level (which is just that found in healthy patients) correlates to 4.9mg/dL.

uric acid concentrations between 3.6 mg/dL (~214µmol/L) and 8.3 mg/dL (~494µmol/L) are considered normal by the American Medical Association

if i understand "normal" correctly, they mean that 'most' people on the bell curve have uric acid levels of 3.6+(8.3-3.6)/2=5.95mg/dL

re: gout, looks like 6mg is the danger zone. that would be over 350µmol/L.

cheers