Re: uric acid
Posted: Sat Nov 25, 2017 12:45 pm
Low serum uric acid levels in patients with acute central nervous system viral infections
http://journals.lww.com/neuroreport/Abs ... te.11.aspx
'Most acute central nervous system (CNS) viral infections lead to either encephalitis or meningitis. Many neurotropic viruses may cause CNS dysfunctions through various mechanisms including oxidative stress. Serum uric acid (SUA) levels, which are associated with oxidative stress and antioxidant status, are reduced in patients with various neurological disorders, including multiple sclerosis. We investigated the possible correlation between SUA levels and clinical disease status in patients with acute CNS viral infections. We measured SUA concentrations in 336 individuals, including 179 healthy individuals and 157 patients with acute CNS viral infections. We found that the patients had lower SUA levels than the healthy individuals did irrespective of sex. Effective therapy significantly increased SUA levels. The patients’ SUA levels were correlated inversely with outcomes as measured with the Glasgow Outcome Scale. SUA levels may be a biomarker for predicting treatment outcomes and prognoses for patients with acute CNS viral infections with inflammatory components.
"In our hospital, the normal SUA range is 208–428 mM for men and 155–357 mM for women...
"... we observed significantly lower SUA levels in patients who had neurological abnormalities (P=0.001), seizures (P=0.006), abnormal EEG results (P<0.001), abnormal MRI findings (P<0.001), or a need for ICU treatment (P<0.001) than in patients who did not have these conditions (Table 4).
.......................................ua in cases with............ua in controls
Neurological abnormalities..181 +/- 82...................225 +/- 69
Cognitive dysfunction.........188 +/- 82...................208 +/- 77
.......................................ua before treatment......ua.after
viral meningitis...................223 +/- 57.................285 +/- 78
viral encephalitis.................205 +/- 96.................261 +/- 100
"SUA levels were evidently decreased in patients with viral CNS infections, but effective treatments restored them. More importantly, lower SUA levels may be related to several phenomena indicative of disease severity, including neurological abnormalities, seizures, abnormal EEG results, abnormal MRI findings, and a need for ICU treatment. Furthermore, lower SUA levels were correlated closely with poor prognoses. Therefore, SUA levels may be a useful biomarker of acute CNS viral infections with inflammatory components and may be useful indicators for prognoses and treatment outcomes."
very interesting. i'd like to have seen a serum zinc test somewhere in this mix.
reference range locally is 140-360. i remember years ago the first time i heard about ua being low in ms (on this forum, btw), had it tested and when it came back 194 i was like "meh, guess ua is fine in MY case" <- jimmylegs, right before figuring out 'normal range' bs
http://journals.lww.com/neuroreport/Abs ... te.11.aspx
'Most acute central nervous system (CNS) viral infections lead to either encephalitis or meningitis. Many neurotropic viruses may cause CNS dysfunctions through various mechanisms including oxidative stress. Serum uric acid (SUA) levels, which are associated with oxidative stress and antioxidant status, are reduced in patients with various neurological disorders, including multiple sclerosis. We investigated the possible correlation between SUA levels and clinical disease status in patients with acute CNS viral infections. We measured SUA concentrations in 336 individuals, including 179 healthy individuals and 157 patients with acute CNS viral infections. We found that the patients had lower SUA levels than the healthy individuals did irrespective of sex. Effective therapy significantly increased SUA levels. The patients’ SUA levels were correlated inversely with outcomes as measured with the Glasgow Outcome Scale. SUA levels may be a biomarker for predicting treatment outcomes and prognoses for patients with acute CNS viral infections with inflammatory components.
"In our hospital, the normal SUA range is 208–428 mM for men and 155–357 mM for women...
"... we observed significantly lower SUA levels in patients who had neurological abnormalities (P=0.001), seizures (P=0.006), abnormal EEG results (P<0.001), abnormal MRI findings (P<0.001), or a need for ICU treatment (P<0.001) than in patients who did not have these conditions (Table 4).
.......................................ua in cases with............ua in controls
Neurological abnormalities..181 +/- 82...................225 +/- 69
Cognitive dysfunction.........188 +/- 82...................208 +/- 77
.......................................ua before treatment......ua.after
viral meningitis...................223 +/- 57.................285 +/- 78
viral encephalitis.................205 +/- 96.................261 +/- 100
"SUA levels were evidently decreased in patients with viral CNS infections, but effective treatments restored them. More importantly, lower SUA levels may be related to several phenomena indicative of disease severity, including neurological abnormalities, seizures, abnormal EEG results, abnormal MRI findings, and a need for ICU treatment. Furthermore, lower SUA levels were correlated closely with poor prognoses. Therefore, SUA levels may be a useful biomarker of acute CNS viral infections with inflammatory components and may be useful indicators for prognoses and treatment outcomes."
very interesting. i'd like to have seen a serum zinc test somewhere in this mix.
reference range locally is 140-360. i remember years ago the first time i heard about ua being low in ms (on this forum, btw), had it tested and when it came back 194 i was like "meh, guess ua is fine in MY case" <- jimmylegs, right before figuring out 'normal range' bs