Prostaglandins Leukot Essent Fatty Acids. 2005 Aug 12;
Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients.
Weinstock-Guttman B, Baier M, Park Y, Feichter J, Lee-Kwen P, Gallagher E, Venkatraman J, Meksawan K, Deinehert S, Pendergast D, Awad AB, Ramanathan M, Munschauer F, Rudick R.
Baird Multiple Sclerosis Center for MS Treatment and Research, Jacobs Neurological Institute, State University of New York, 100 High Street, Buffalo General Hospital-E2, Buffalo, NY 14203, USA.
Objectives: To determine whether a low fat diet supplemented with omega-3 positively affects quality of life (QOL) in relapsing-remitting MS (RRMS) patients. In this 1-year long double-blind, randomized trial, patients were randomized to two dietary interventions: the "Fish Oil" (FO) group received a low fat diet (15% fat) with omega-3 FOs and the "Olive Oil" (OO) group received the AHA Step I diet (fat 30%) with OO supplements.
The primary outcome measure was the Physical Components Summary Scale (PCS) of the Short Health Status Questionnaire (SF-36). Additional measures using MS specific QOL questionnaires, neurological status and relapse rate were obtained.
Results: 31 RRMS patients were enrolled, with mean follow up over 11+/-SD 2.9 months. Clinical benefits favoring the FO group were observed on PCS/SF-36 (P=0.050) and MHI (P=0.050) at 6 months. Reduced fatigue was seen on the OO diet at 6 months (P=0.035). The relapse rate decreased in both groups relative to the rates during the 1 year preceding the study: mean change in relapse rate in the FO group: -0.79+/-SD 1.12 relapses/year (P=0.021) vs. -0.69+/-SD 1.11 (P=0.044) in the OO group.
This study suggests that a low fat diet supplemented with omega-3 PUFA can have moderate benefits in RRMS patients on concurrent disease modifying therapies.
Oregon Health & Science University Studying OMEGA-3s As Treatment For MS Depression
August 23, 2005 - Oregon Health & Science University researchers want to know if depression, particularly among multiple sclerosis patients, is the latest illness that can be reeled in with omega-3 fatty acids found in fish.
A clinical trial is under way in the OHSU School of Medicine's Department of Neurology to determine whether omega-3 supplementation, in the form of fish oil capsules, improves the therapeutic effects of antidepressants for depression in MS patients. Depression is a common MS symptom, which affects 50 percent to 60 percent of this population.
The study is funded by the National Institutes of Health's National Center for Complementary and Alternative Medicine.
Lynne Shinto, N.D., OHSU assistant professor of neurology, is leading the randomized, double-blind, placebo-controlled trial expected to involve 60 research subjects ages 18 to 65 who have MS and suffer from mild to moderate depression. Participants are being split into two groups - one taking doses of 6 grams per day of fish oil capsules and the other taking a placebo - and will be followed for three months.
All subjects are allowed to continue taking antidepressant and MS medications while participating in the study. Those experiencing significant improvement in their depression can continue treatment for another three months so scientists can evaluate the longer-term effects of fish oil.
Shinto hopes to find out not only whether omega-3s show clinical benefits for MS depression, but also whether they reduce the levels of inflammatory agents believed to contribute to both depression and MS.
"The primary outcome is clinical. We would like to see a decrease in depression, but we also want to see if the clinical benefit is associated with a reduction of inflammatory markers," she said. "My hope is to use an agent that may be beneficial for both MS and depression. It's thinking holistically about MS depression."
Although the cause of MS is still unknown, it is believed that damage in the central nervous system results from a small group of white blood cells, which normally defend against infection in the human body, that are misdirected to attack myelin, the fatty sheath insulating nerve fibers in the brain and spinal cord. As a result, the fibers can't conduct impulses, leading to such MS symptoms as walking difficulties, memory loss, dizziness, fatigue, bladder dysfunction, vision problems, pain, imbalance, and depression. Fish-based omega-3s are believed to decrease the levels of inflammatory agents, cytokines, secreted in the blood that are involved in the demyelinization of nerve fibers.
"They're really anti-inflammatory," Shinto said of omega-3s. "Inflammation in the central nervous system is one of the causes of demyelinization, which results in MS symptoms. It is interesting that now there is a body of scientific evidence linking inflammation to depression in non-MS patients. I thought maybe the high rate of depression in MS could be related to inflammation and, in that case, omega-3 fatty acids could benefit both depression and MS."
Fish oil, particularly that of cold water fish such as salmon, mackerel, lake trout and tuna, contains high levels of two kinds of omega-3 fatty acids, eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. They are believed to help improve heart health, reduce blood pressure, improve rheumatoid arthritis and lupus, and aid in cancer prevention.
Fish oil supplementation is reported to cause few side effects in subjects with depression who were on stable doses of antidepressant medication. The OHSU study will be the first to rigorously evaluate the effectiveness of a popular supplement, when taken with antidepressant, in people with MS.
Shinto is leading another OHSU study examining whether fish oil alone and a combination of fish oil and alpha lipoic acid (ALA) show benefits for people with Alzheimer's disease. The study already has shown that most subjects experience no serious side effects, after 6 months, when taking fish oil in combination with medications for dementia.
Volunteers are being recruited for the study. For more information, call the OHSU MS Center of Oregon's research line at 503 494-7963. Callers will be given an initial qualifying screening over the phone.
http://www.medfordnews.com/articles/ind ... 9&cp=10996
Hubby is lucky he does not suffer from depression.
Cut up 4 lbs carrots
1 - 3 inch ginger root peeled
4 cloves garlic
2 TBS of olive oil
Put all in a pot and caramelize
Then add 4 cans chicken soup broth with 4 cans water. Simmer for 3 hours salt and pepper to taste. Then blend and serve hot. Awesome
This is the best soup ever and just so healthy. I have a 1000 recipes just ask. Low fat heart healthy. It is a meal by itself with a nice flax loaf and a salad.
For what it's worth, the July 2003 issue of Consumer Reports ran an article on fish oil supplements. The article, available by subscription via the web or at your local library, examined 16 different brands of omega-3 fish oil supplements and found that "none contained significant amounts of mercury, PCBs, or Dioxin." They also found "no significant difference in quality or purity" between the inexpensive brands such as Costco's Kirkland Signature brand and more expensive brands such as Spectrum Essentials and Solgar. Unfortunately, specific data was not presented in the article as it just summarizes the results from their labs as well as "two independent labs." More specific data may or may not be available directly from Consumer Reports.Melody wrote:We do not use fish oil capsules as I'm a tad worried about mercury content as it is higher in capsules then in fish itself although some argue that.
With that said, I'm also convinced by the available published data that omega-3 fish oil offers benefit for MS. I take about 2.5g/day of omega-3 fish oil, as well as 1g/day cod liver oil, and 9g/day (1 Tbsp.) of ground flax seed. Although this is an older paper from 1995, it had a positive influence in my decision to start omega-3 supplementation after I was diagnosed in 1999.
I should also note for anyone interested that I also take 400IU/day of natural Vitamin E, 50mg/day of R-Lipoic Acid, 500mg/day of Vitamin C, and about 4 cups/day of strongly brewed green tea in addition to Avonex (which I've been on for 5 years). So far I've had no major relapses since my diagnosis, just the same old chronic neuropathic pain in one leg I've had which fluctuates from day-to-day. However, as I recently discovered on a hiking trip last week, I'm definitely not in the same shape I used to be. What used to be a 2.5 hour hike now took 6.25 hours and I was really grateful that I was given a very functional walking stick at the start (it kept me vertical on many occasions too numerous to count).
http://www.thisisms.com/modules.php?nam ... pic&t=1121
I was wondering if anyone could reccomend a specific brand of lemon flavored cod liver oil that was good and a good supplier over the internet to order it from.
- Family Elder
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Or others from this page:
http://search.store.yahoo.com/cgi-bin/n ... iver%20oil
They are very good for most other things as well!
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