a healthy gut

[jimmylegs]

Interrelation of Diet, Gut Microbiome, and Autoantibody Production (2018)
https://www.frontiersin.org/articles/10 ... 00439/full

B cells possess a predominant role in adaptive immune responses via antibody-dependent and -independent functions. The microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact on various immune responses, including B cell maturation, activation, and IgA antibody responses. Recent findings have demonstrated the interplay between dietary components, gut microbiome, and autoantibody production. “Western” dietary patterns, such as high fat and high salt diets, can induce alterations in the gut microbiome that in turn affects IgA responses and the production of autoantibodies. This could contribute to multiple pathologies including autoimmune and inflammatory diseases. Here, we summarize current knowledge on the influence of various dietary components on B cell function and (auto)antibody production in relation to the gut microbiota, with a particular focus on the gut–brain axis in the pathogenesis of multiple sclerosis.

on the right track
healthy lifestyle > optimal macro and micro nutrient status > healthy microbiome > healthy immune system

[jimmylegs]

Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry (2017)
https://www.sciencedirect.com/science/a ... 441630264X

The microbial population residing within the human gut represents one of the most densely populated microbial niche in the human body with growing evidence showing it playing a key role in the regulation of behavior and brain function. The bidirectional communication between the gut microbiota and the brain, the microbiota-gut-brain axis, occurs through various pathways including the vagus nerve, the immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and the behavior that are often associated with neuropsychiatric conditions. Therefore, research targeting the modulation of this gut microbiota as a novel therapy for the treatment of various neuropsychiatric conditions is gaining interest. Numerous factors have been highlighted to influence gut microbiota composition, including genetics, health status, mode of birth, and environment. However, it is diet composition and nutritional status that has repeatedly been shown to be one of the most critical modifiable factors regulating the gut microbiota at different time points across the lifespan and under various health conditions. Thus the microbiota is poised to play a key role in nutritional interventions for maintaining brain health.

[jimmylegs]

The gut microbiota and cardiovascular health benefits: A focus on wholegrain oats (2018)
https://onlinelibrary.wiley.com/doi/ful ... /nbu.12354

Abstract
'Existing scientific data suggest that a high intake of wholegrain foods contributes to improved gut health and a reduced risk of cardiovascular disease. Wholegrain oats are rich in dietary fibre and an important source of many bioactive components, including minerals, vitamins and phenolic compounds. The oat β‐glucans have been reported to lower low‐density lipoprotein cholesterol through their ability to increase the viscosity of intestinal chime, change the gut microbiota composition and increase the production of short‐chain fatty acids, which may contribute to the inhibition of hepatic cholesterol synthesis. Oats are also a rich source of phenolic acids, which are predominantly bound to cell wall polysaccharides through ester bonds. This bound state within oats means that phenolic acid bioavailability will largely be determined by interactions with the colonic microbiota in the large intestine. However, results from in vitro, animal and human studies have been inconsistent in relation to the impact of oats on the gut microbiota, possibly due to differences in experimental techniques and because compounds in oats, other than β‐glucans, have not been considered. This review focuses on the interaction of oat β‐glucans and phenolic acids with gut microbiota, and the subsequent link to cardiovascular health."

not sure what high is supposed to mean. my personalized food guide says 6 half cup servings per day. that's the canadian guide though, which pushes grains a bit more than the US version. (they seem to emphasize 'whole' a bit better mind you)

[jimmylegs]

i post this info with the caveat that you can readily implement vegetarian diet poorly and end up with an msdx, as has been my own experience not to mention others eg terry wahls.

'more veg good' depends on your starting point and IS NOT EQUAL to 'all veg better'.

Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status (2018)
https://www.nature.com/articles/s41598-018-28839-3

In summary, this study provides important insights into the role of diet in a spontaneous EAE model that is relevant for human MS. Epidemiological studies have shown that countries with a high intake of saturated fat have higher risk to develop MS than in countries with a high intake of polyunsaturated fat26. In addition, diets rich in fiber and omega 3 fatty acids have been encouraged for MS. However, these studies are merely anecdotal, and our study clearly warrants more systematic studies in humans. Interestingly, although case-control studies have found MS risk to be associated with animal fat or animal product consumption, or a protective effect of vegetable fats, Omega-3 and 6 fatty acids showed limited effects in controlled trials27,43. Our finding that dietary cellulose, which is high in vegetables, is likely protective through a monounsaturated omega-9 fatty acid fatty acid (cis-11 eicosenoic acid) common in plant oil and nuts suggests a potential reason for the beneficial effects of vegetable fat. The fact that vegetarian diet can be easily consumed in daily life, makes it a useful supplementation to the currently available medications. In addition, cis-11 eicosenoic acid could be tested as a supplement or treatment in human MS. Clearly, our findings warrant more nutritional studies in human MS, a field that is severely understudied with merely anecdotal evidence despite the substantial interest among MS patients to adjust their diet to improve health prospects.

[DIM]

Neuroscientists discover new way to disrupt chronic inflammation responsible for multiple sclerosis

https://www.news-medical.net/news/20230 ... rosis.aspx

“... Gaultier and his collaborators blocked the activity of the regulator, called "aryl hydrocarbon receptor," in immune cells called T cells and found that doing so had a dramatic effect on the production of bile acids and other metabolites in the microbiomes of lab mice. With this receptor out of commission, inflammation decreased and the mice recovered. ...”

[NHE]

The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation
PLoS Biol. 2023 Feb 14;21(2):e3002000.

Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune system regulator responsive to nonpathogenic external stimuli is the aryl hydrocarbon receptor (AHR). The AHR, which binds diverse molecules present in the environment in barrier tissues, is a therapeutic target for MS. However, AHR's precise function in T lymphocytes, the orchestrators of MS, has not been described. Here, we show that in a mouse model of MS, T cell-specific Ahr knockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids. Our study demonstrates a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.

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