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In our lab they can perform all tests but told us sTfR is transferin test although I believe we talk about different things here.
Should I ask them exactly sTfR or transferin is the same parameter?
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soluble transferrin receptor is the expression of transferrin receptor found in the blood...so if they test your wife's blood level of transferrin receptor, they are testing her sTfR. In bloodwork, its' considered the same thing.
Here's the study I posted earlier in the thread.Background Iron is essential for virtually all types of cells and organisms. The significance of iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells. Iron imbalance is associated with proinflammatory cytokines and oxidative stress, which have been implicated in the pathogenesis of multiple sclerosis (MS). Transferrin receptor (TfR) is the major mediator of iron uptake. Its expression is increased to facilitate iron entrance into the cell. The increased serum level of soluble transferrin receptor (sTfR) may indicate an abnormal intracellular distribution of iron and a decrease in the cytoplasmic compartment.
dx dual jugular vein stenosis (CCSVI) 4/09
The body stores and moves iron around the body by binding it to proteins like haemoglobin.
The average person contains only 3 to 5 grams of iron. None of it is "loose" it is all bound to proteins. Most of the iron in the body is not stored but is currently being used ("functional"). Approximately 60% of all iron is being used by the haemoglobin of red blood cells at any one time. Most of the rest is stored in the liver and spleen.
Transferrin is a blood plasma protein that initially transports iron from the gut to the cells. Only about 2% of the body's iron is bound to this. Serum iron measures the amount of iron in blood plasma, i.e. circulating iron that is currently bound to transferrin (Whereas serum transferrin is the % of transferrin, i.e. blood plasma protein, that has iron bound to it). Total Iron Binding Capacity (TIBC) - measures the total amount of transferrin.
Confused already? There's more!....
Ferritin is also a protein that stores iron. However, it stores iron in tissue all over the body. It also releases iron, enabling the body to avoid iron deficiency and to some degree prevent too much iron. Serum ferritin is simply the total amount of stored iron in the body.
A transferrin receptor is a kind of docking mechanism for iron within each cell - the means by which iron is allowed in, for example to facilitate energy release. Higher concentrations of these receptors may indicate an iron shortage.
Hope this helps. I think it's important we all know as much about iron as possible so we can all understand the amazing recent research findings. I believe a lot is at stake here!
They can only tell me they perform this test, I am curious to see what are the normal levels so I'll find what they mean.
do you take iron in pill form?
also, as peek mentioned iron excess can be a problem in autoimmune conditions BUT the good news is that zinc can help.
having low iron can bring your zinc down, and zinc is low in ms-ers too.
when zinc is low, so is uric acid (low uric acid is another of the usual suspects in ms).
personally i like to keep my iron level well out of the deficient ballpark. i got my zinc up to 16 umol/L and it raised my uric acid from 194 to 278 umol/L - i am aiming for 18 and 290-300.
having a good zinc status helps your body manage iron properly.
i agree that bcomplex is another good option for energy, but iron deficiency is so common and you have that bad level and the alopecia..
what have you tried up til now?
will be interesting to see how the zinc and uric acid come back
from what i've just read, it doesn't seem to make sense to have low zinc and high lipase. will keep reading more about lipase to get a better handle.
if you don't mind my asking, what are some of those amounts per day - on the d3, cal, mag, potassium, those kinds of thing?
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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