Re: NAD+ for mitochondria
Posted: Fri Feb 24, 2017 5:38 pm
I tried Niagen for 3 months and Basis for 2 months. Neither of these nicotinamide riboside products made any change to energy level. I was trying to see if it could do anything like a B vitamin that does give me a tremendous energy boost.
Since 2014 I've been using niacin ER as a sublingual to induce a flush and increase mobility.
600-800 mg niacin is what I take as sublingual to generate a flush, which allows to go from wheelchair only to walking with walker up to 100 ft. Exercise for 60 min (peddling, core strength, arm weights). Stiffness is gone from legs.
If you try this start small with 50 mg and work your way up. Use a pill crusher, put the power under tongue. It's very intense, so be careful. You will get used to it eventually, but at first it is an uncomfortable, itchy sunburn feeling.
Managed to time the flush right last week and blew back my neuro's hair when I jumped up and headed down the hall with a walker for 50 feet. The doc kept saying "I've never heard of this"
The clinical pharmacist suggested Prozac as a vasodilator (that's why Raynaud's patients use it). It does have 2 MS trials but they reported MRIs, not mobility results.
So have I found a way to unlock the NAD fire hose, or is it vasodilation, and the oxygen allows better mobility?
So is it
A) As a precursor to NADH, niacin provides electrons for ATP synthesis that fuels mitochondria & energy.
per http://nootropicsexpert.com/vitamin-b3-niacin/
“Any condition associated with poor mitochondrial function, such as chronic fatigue syndrome… may well benefit from niacinamide supplementation.”
But can NAD+ create such a dramatic energy increase in just 20 minutes, enough to get me walking?
Or is it
B) The mechanism and mitigation of niacin-induced flushing
Niacin activates the arachidonic acid cascade to induce vasodilatation. Niacin activates the G-protein coupled receptor 109A (GPR109A) to increase cAMP and releases arachidonic acid from cell membranes. Arachidonic acid is metabolised to produce prostaglandins, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/
There is some historical info on the flush effect. Richard Brickner's original paper "Phenomenon of relief by flush in multiple sclerosis" from the 1950's, they mainly used Amyl Nitrite, CO2 and histamine phosphate USP to achieve the flush, but they did occasionally use Nicotinic Acid. I found a paper that summarized all the subsequent work done in this direction, but the authors dismiss it because it was observational reports; controlled studies weren't as common in the 1950's. Also they seemed to building a case towards the end argument that expanding veins to treat CCSVI was pointless.
'On the historical succession of vessel-based therapies in the treatment of multiple sclerosis'
https://www.academia.edu/attachments/45 ... ?s=regpath
Since 2014 I've been using niacin ER as a sublingual to induce a flush and increase mobility.
600-800 mg niacin is what I take as sublingual to generate a flush, which allows to go from wheelchair only to walking with walker up to 100 ft. Exercise for 60 min (peddling, core strength, arm weights). Stiffness is gone from legs.
If you try this start small with 50 mg and work your way up. Use a pill crusher, put the power under tongue. It's very intense, so be careful. You will get used to it eventually, but at first it is an uncomfortable, itchy sunburn feeling.
Managed to time the flush right last week and blew back my neuro's hair when I jumped up and headed down the hall with a walker for 50 feet. The doc kept saying "I've never heard of this"
The clinical pharmacist suggested Prozac as a vasodilator (that's why Raynaud's patients use it). It does have 2 MS trials but they reported MRIs, not mobility results.
So have I found a way to unlock the NAD fire hose, or is it vasodilation, and the oxygen allows better mobility?
So is it
A) As a precursor to NADH, niacin provides electrons for ATP synthesis that fuels mitochondria & energy.
per http://nootropicsexpert.com/vitamin-b3-niacin/
“Any condition associated with poor mitochondrial function, such as chronic fatigue syndrome… may well benefit from niacinamide supplementation.”
But can NAD+ create such a dramatic energy increase in just 20 minutes, enough to get me walking?
Or is it
B) The mechanism and mitigation of niacin-induced flushing
Niacin activates the arachidonic acid cascade to induce vasodilatation. Niacin activates the G-protein coupled receptor 109A (GPR109A) to increase cAMP and releases arachidonic acid from cell membranes. Arachidonic acid is metabolised to produce prostaglandins, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/
There is some historical info on the flush effect. Richard Brickner's original paper "Phenomenon of relief by flush in multiple sclerosis" from the 1950's, they mainly used Amyl Nitrite, CO2 and histamine phosphate USP to achieve the flush, but they did occasionally use Nicotinic Acid. I found a paper that summarized all the subsequent work done in this direction, but the authors dismiss it because it was observational reports; controlled studies weren't as common in the 1950's. Also they seemed to building a case towards the end argument that expanding veins to treat CCSVI was pointless.
'On the historical succession of vessel-based therapies in the treatment of multiple sclerosis'
https://www.academia.edu/attachments/45 ... ?s=regpath