Yet Again, Serum Zinc Concentrations Unrelated to Intake

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Yet Again, Serum Zinc Concentrations Unrelated to Intake

Post by jimmylegs » Sat Sep 29, 2018 3:03 pm

this just in: useless zinc intakes (7 mg/d) don't make an appreciable difference to serum zinc levels!!!

*whew* how lucky am i that my stupid doctor's advice to take 100 mg/d, ie over 10 times useless, actually *does* do something (ie more than doubles serum levels), or my serum zinc would have been deficient to this day! s. m. h. :?

Yet Again, Serum Zinc Concentrations Are Unrelated to Zinc Intakes (2018) ... 99/5079797

Data from NHANES 2011–14 surveys, reported in the August 2018 issue of the Journal, showed that the serum zinc concentrations of the 4347 children, men, and women surveyed were unrelated to their zinc intake from either diet or supplements (1). This is not the first report that serum zinc concentrations are unrelated to zinc intakes. Three recent meta-analyses came to the same conclusion (2–4). Data from 10 randomized controlled trials and 3 observational studies in adults showed that doubling zinc intake changed the serum or plasma zinc concentrations by 6%. Thus, an adult consuming 14 mg Zn/d has a serum concentration that is only 6% higher than that of an individual consuming 7 mg/d. (The differences between serum and plasma zinc concentrations are very small and these 2 sources of circulating zinc are used interchangeably. The term serum zinc concentrations will be used throughout this paper when the source may be serum or plasma.) A 6% difference falls within the margin of error in measuring serum zinc. In fact, it represents only about one-fourth of the usual 22% drop in serum zinc concentrations from the peak fasting morning value to the lowest evening value about 3–4 h after the last meal (5). Meta-analyses done in children and pregnant or lactating women also found small changes in serum zinc when dietary zinc was doubled (3, 4). Doubling dietary zinc predicted a 9% increase in serum zinc concentrations in children, a 3% increase in pregnant women, and only a 1% increase in lactating women. These results along with the NHANES data in the August 2018 issue (1) suggest that strong homeostatic mechanisms are in place to prevent deviations in serum zinc when dietary intakes fluctuate.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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