2006 study: Vitamin D insufficiency...role of mag deficiency

[jimmylegs]

i should have filed this here years ago. it's been kicking around the forum since 2013:

Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency (2006)

"intro: Vitamin D insufficiency is common, however within individuals, not all manifest the biochemical effects of PTH excess. This further extends to patients with established osteoporosis. The mechanism underlying the blunted PTH response is unclear but may be related to magnesium (Mg) deficiency.

methods: 30 patients (10 women in 3 groups) were evaluated prospectively measuring calcium, PTH, Mg retention (Mg loading test), dietary nutrient intake (calcium, vitamin D, Mg) and bone turnover markers (serum CTX & P1CP).

results: All subjects, within the low vitamin D and low PTH group following the magnesium loading test had evidence of Mg depletion ... Following oral supplementation bone turnover increased

conclusions: This study confirms that in patients with established osteoporosis, there is also a distinct group with a low vitamin D and a blunted PTH level and that Mg deficiency (as measured by the Mg loading test) is an important contributing factor."

[NHE]

Here's a link to the full abstract.

Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Osteoporos Int. 2006;17(7):1013-21.

https://www.ncbi.nlm.nih.gov/pubmed/16596461