re zinc status, histamine release and allergy

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jimmylegs
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Inhibition of Histamine Response by Zinc

Post by jimmylegs » Sat Feb 17, 2018 2:48 pm

Inhibition of Histamine Response by Zinc
https://www.karger.com/Article/Abstract/135963

"Zinc cream has been used for many years in the treatment of skin conditions and allergy. In modern times it has been replaced by cortisone and antihistamine. Zinc has also recently been advised in cases of malnutrition, where zinc levels are low, to aid wound healing.
In this paper we have investigated the effect of zinc on histamine and SRS responses as histamine and SRS play a part in allergy (Kellaway and Trethewie, 1940) and histamine and zinc stimulate healing in wounds."

can't get full text :( it is just guinea pigs though...

not a rich vein of research out there using "serum histamine" and "serum zinc"
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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Re: Inhibition of Histamine Response by Zinc

Post by jimmylegs » Sat Feb 17, 2018 3:15 pm

kind of thing that *is* available

Association between itching and the serum zinc levels in patients with varicose veins
fft: https://www-ncbi-nlm-nih-gov.proxy.lib. ... MC5609042/

"The zinc content was significantly lower in the patients with itching (72.5 ± 7.1 μg/dL) compared to that in the control group (79.1 ± 8.1 μg/dL) (p < 0.05)"

ire 11.1 umol/L vs 12.1 umol/L ie deficient vs nearly so

https://www-ncbi-nlm-nih-gov.proxy.lib. ... gure/Fig3/

sadly, histamine only comes into it in the references.

12. Sanada S, Kuze M, Yoshida O. Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels. Hinyokika Kiyo. 1987
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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jimmylegs
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Re: Inhibition of Histamine Response by Zinc

Post by jimmylegs » Sat Feb 17, 2018 3:52 pm

Serum zinc concentrations in patients on maintenance hemodialysis and its relationship with anemia, parathyroid hormone concentrations and pruritus severity
fft: http://www.sjkdt.org/article.asp?issn=1 ... -Khavidaki

Some authors proposed Zn deficiency as a possible cause of histamine release and the de­velopment of uremic pruritus in HD patients...

...Control group included healthy volunteers who were matched in age and sex with the case group and did not use any supplementary Zn products or were not on severe weight reducing diet...

...The mean serum Zn concentration in patients on maintenance HD was significantly lower than that of the control group (69.16 ± 17.29 μg/dL vs 82.93 ± 14.75 μ/dL; P= 0.001); how­ever, it was not different with the cut-off point of 70 μ/dL that is recommended by Gibson [7] (P= 0.66)....

...we did not find any correlation bet­ween serum Zn concentration of the patient and their pruritus severity, a Japanese study suggests that Zn deficiency may participate in increase histamine level in HD patients and result in the development of uremic pruritus. Oral Zn sulfate supplementation relieved pru­ritus in 53% of their patients. They explained this finding with the inhibitory effect of Zn on various functions of some cells including mast cells.

so 10.6 umol/L vs 12.7 umol/L

again, deficient vs nearly so. would rather they'd actually measured histamine than pruritis severity.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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re zinc status, histamine release and allergy

Post by jimmylegs » Fri Dec 28, 2018 9:29 am

more:
  • Nishida, K., & Uchida, R. (2018). Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses. Journal of Immunology Research, 2018.
    "Zinc is essential for maintaining normal structure and physiological function of cells. Its deficiency causes growth retardation, immunodeficiency, and neuronal degeneration. Zinc homeostasis is tightly regulated by zinc transporters and metallothioneins that control zinc concentration and its distribution in individual cells and contributes to zinc signaling. The intracellular zinc signaling regulates immune reactions. Although many molecules involved in these processes have zinc-binding motifs, the molecular mechanisms and the role of zinc in immune responses have not been elucidated. We and others have demonstrated that zinc signaling plays diverse and specific roles in vivo and in vitro in studies using knockout mice lacking zinc transporter function and metallothionein function. In this review, we discuss the impact of zinc signaling focusing particularly on mast cell-, basophil-, and T cell-mediated inflammatory and allergic responses. We also describe zinc signaling dysregulation as a leading health problem in inflammatory disease and allergy."
  • Najafabadi, M. M., Faghihi, G., Emami, A., Monghad, M., Moeenzadeh, F., Sharif, N., & Davarpanah Jazi, A. H. (2012). Zinc sulfate for relief of pruritus in patients on maintenance hemodialysis. Therapeutic Apheresis and Dialysis, 16(2), 142-145.
    "According to the inhibitory effects of zinc on histamine release and reported low levels of serum zinc in hemodialysis patients, we aimed to evaluate the effects of zinc sulfate for the relief of pruritus in these patients."
  • Sanada, S., Kuze, M., & Yoshida, O. (1987). Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels. Hinyokika kiyo. Acta urologica Japonica, 33(12), 1955-1960.
    "In this study, we examined the serum zinc and histamine levels in 19 hemodialysis patients with persistent pruritus and the effect of zinc supplementation on the pruritus. In patients with pruritus, the serum zinc level decreased and serum histamine level increased, showing a negative correlation between them. Oral zinc sulfate, 445 mg daily for two months, relieved pruritus subjectively in 53% of the patients. After treatment, serum histamine levels decreased significantly, as well as serum zinc levels increased significantly. These findings suggest that zinc deficiency participates in increased histamine levels in dialysis patients, and subsequently in the development of uremic pruritus."
  • Marone, G., Columbo, M., De Paulis, A., Cirillo, R., Giugliano, R., & Condorelli, M. (1986). Physiological concentrations of zinc inhibit the release of histamine from human basophils and lung mast cells. Agents and actions, 18(1-2), 103-106.
    "We have previously shown that physiological concentrations of zinc (≃ 7× 10− 6 M) inhibit the release of histamine from human basophil leukocytes (Marone et al., J. Pharmacol. Exp. Ther. 217: 292, 1981)."
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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