55 Ways to Promote Myelination

[NHE]

55 Natural Ways to Increase Myelin Sheath + Function & Facts
https://selfhacked.com/blog/myelin/

Myelin is an important part of the nervous system and is vital for optimal cognitive function. Read on to learn more about its purpose and how you can increase myelin in your body.

[ElliotB]

The article you linked to is excellent - one of the best I have read. And should be considered a 'must' read IMHO for anyone with MS. Thanks for posting it!

[Petr75]

Very good

[NHE]

My only problem with the article is the recommendation to use grape seed extract. Some researchers have found that it promotes interferon-gamma which is known to be bad for MS.

https://www.ncbi.nlm.nih.gov/pmc/articl ... f/0214.pdf

[Petr75]

2019 Jun
The Key Research Laboratory Study of Beneficial Qi as a Blood Circulation Stimulator in the Treatment of Multiple Sclerosis, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, China
Therapeutic effect of oligomeric proanthocyanidin in cuprizone-induced demyelination
https://www.ncbi.nlm.nih.gov/pubmed/30811744

Abstract
NEW FINDINGS:
What is the central question of this study? Oligomeric proanthocyanidin has the capacity to alleviate abnormalities in neurological functioning. However, whether oligomeric proanthocyanidin can reduce the progression of demyelination or promote remyelination in demyelinating diseases remains unknown. What is the main finding and its importance? Oligomeric proanthocyanidin can improve cuprizone-induced demyelination by inhibiting immune cell infiltration, reversing overactivated microglia, decreasing the inflammatory cytokines secreted by inflammatory cells and decreasing the production of myelin oligodendrocyte glycoprotein35-55 -specific antibody in the brain.
ABSTRACT:
Demyelinating diseases of the CNS, including multiple sclerosis, neuromyelitis optica and acute disseminated encephalomylitis, are characterized by recurrent primary demyelination-remyelination and progressive neurodegeneration. In the present study, we investigated the therapeutic effect of oligomeric proanthocyanidin (OPC), the most effective component of grape seed extract, in cuprizone-fed C57BL/6 mice, a classic demyelination-remyelination model. Our results showed that OPC attenuated abnormal behaviour, reduced demyelination and increased expression of myelin basic protein and expression of O4+ oligodendrocytes in the corpus callosum. Oligomeric proanthocyanidin also reduced the numbers of B and T cells, activated microglia in the corpus callosum and inhibited secretion of inflammatory factors. Furthermore, concentrations of myelin oligodendrocyte glycoprotein-specific antibodies were significantly reduced in serum and brain homogenates after OPC treatment. Together, these results demonstrate a potent therapeutic effect for OPC in cuprizone-mediated demyelination and clearly highlight multiple effects of this natural product in attenuating myelin-specific autoantibodies and the inflammatory microenvironment in the brain.

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