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NHE
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by NHE » Mon Nov 25, 2019 5:46 pm
Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis.
Complement Ther Med. 2018 Dec;41:169-174.
- BACKGROUND: Gait and balance impairment is common in secondary progressive multiple sclerosis (SPMS). Lipoic acid (LA), an over-the-counter antioxidant, is effective in MS animal models and may improve walking speed, but effects on mobility are unreported.
OBJECTIVE: Examine the effects of 1200 mg daily oral dose of LA versus placebo (PLA) on gait and balance in a 2-year, randomized, double-blind pilot study.
METHODS: 134 participants were screened for eligibility before assignment to LA (n = 28) or PLA (n = 26). Included here were, 21 participants with SPMS who took LA (N = 11) or PLA (N = 10) capsules for 2 years (enrolled May 2, 2011 - August 14, 2015) and completed all tasks without the use of an assistive device. Participants completed the Timed Up and Go (TUG) and quiet standing tasks every 6 months while wearing inertial sensors (APDM Opals) to quantify mobility.
RESULTS: LA had a medium effect on time to complete TUG at 2 years (g = 0.51; 95% CI = -0.35, 1.38). In a subset of 18 participants with less disability (EDSS < 6, no use of ambulatory device), turning time was significantly shorter with LA (p = 0.048, Δ= 0.48 s). No differences in balance metrics were found between groups.
CONCLUSIONS: LA had an effect on walking performance in people with SPMS, particularly in those with lower baseline disability.
TRIAL REGISTRATION: Lipoic Acid for Secondary Progressive Multiple Sclerosis https://clinicaltrials.gov/ct2/show/NCT ... cid&rank=1 NCT0118881.
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Lipoic acid helps clear iron accumulation in PD model
Replies: 3
First post
Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
Front...
Last post
Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation
Oxid...
- 3 Replies
- 402 Views
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Last post by NHE
Wed Dec 02, 2020 4:46 am
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Walking
2020 Jan 9
Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, United States.
Physical activity and peak oxygen...
- 0 Replies
- 804 Views
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Last post by Petr75
Wed Jan 22, 2020 11:33 am
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CBD helps with anxiety
Cannabidiol in Anxiety and Sleep: A Large Case Series
The Permanente Journal. 2019; 23:18-041.
Context: Cannabidiol (CBD) is one of many...
- 0 Replies
- 427 Views
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Last post by NHE
Wed Jun 17, 2020 12:45 am
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- 197 Views
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Last post by NHE
Wed Oct 14, 2020 7:12 am
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Propionic Acid
Replies: 3
First post
2020 Mar 5
Department of Neurology, Ruhr University Bochum, St. Josef Hospital Bochum, Germany
Propionic Acid Shapes the Multiple Sclerosis Disease...
Last post
I was able to find sodium propionate sold as a food grade additive for inhibiting mold in baked goods. Would that work? What about the dosage?
- 3 Replies
- 739 Views
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Last post by NHE
Tue Mar 17, 2020 10:30 pm
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Bile Acid
Replies: 1
First post
2020 Mar 17
Department of Neurology, Johns Hopkins University, Baltimore
Bile Acid Metabolism Is Altered in Multiple Sclerosis and Supplementation...
Last post
2020 Aug 20
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin
Bile Acid Signaling in Neurodegenerative...
- 1 Replies
- 599 Views
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Last post by Petr75
Sun Sep 20, 2020 2:00 am
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Lipoic acid in autoimmune disease
Replies: 4
First post
The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases.
Biomed Res Int. 2019 Mar 20;2019:8086257.
Αlpha-lipoic acid is a...
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Although Lipoic acid is not cheap, it is not expensive either and as such there is little money to be made with it from BIG pharma so I doubt this...
- 4 Replies
- 6501 Views
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Last post by NHE
Mon Aug 05, 2019 3:33 pm
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Very long chain fatty acid
2019 Jun
Université de Bourgogne Franche-Comté, Dijon, F-21000, France; Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism',...
- 0 Replies
- 833 Views
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Last post by Petr75
Tue May 21, 2019 7:58 am
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- 0 Replies
- 866 Views
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Last post by Petr75
Tue Mar 12, 2019 11:35 am