Zn, Cu, Mn and Fe in neurodegenerative diseases
• Excessive metal levels induce neurodegeneration by oxidative stress, disrupting mitochondrial function, and cell death.
• The role of zinc (Zn), copper (Cu), manganese (Mn), and iron (Fe) in Alzheimer disease, Parkinson disease, and multiple sclerosis was reviewed.
• Zn deficiency and high levels of Cu, Mn, and Fe participate in the activation of nuclear factor kappa B and induce inflammatory and oxidative stress.
• High levels of Cu, Mn and Fe participate in the formation of intracellular inclusions, called Lewy Body, a marker of Parkinson disease.
•Zn deficiency induces an imbalance of Th1/Th2 cells and a failure of Th17 downregulation, contributing to multiple sclerosis pathogenesis."
since late 2019 i have specifically been using therapeutic oral zinc to simultaneously manage low normal zinc, high normal ferritin and high normal copper. still a work in progress.