The impact of vitamin D3 intake on inflammatory markers in multiple sclerosis patients and their first-degree relatives
https://journals.plos.org/plosone/artic ... ne.0231145
Background & aims: In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. In this paper, however, it is intended to extend the mentioned model by assessing the expression mRNA levels of IL-27 and TGF-β1 as well as the changes of plasma levels of IL-27, TGF-β1, IL-17A, IL-10, and IL-6 after treatment by vitamin D3.
Method: Venous blood samples were drawn from Healthy Participants (HP, n = 25) and First-Degree Relative Participants (FDRP, n = 25) as control groups and Multiple Sclerosis Participants (MSP, n = 25) before and after eight weeks of supplementation with 50000 IU vitamin D3. The mRNA expression and plasma concentrations were gauged by using Real-Time PCR and ELISA assay, respectively.
Results: The mRNA surfaces of IL-27, as well as TGF-β1, were up-regulated. However, the plasma levels of TGF-β1, IL-17A, and IL-6 were significantly different among the three groups. In addition, the plasma levels of IL-27, TGF-β1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3.
Conclusion: The findings of this paper illustrate that anti-inflammatory cytokines could have a key role in immunomodulatory functions due to their anti-inflammatory functions. To conclude, this might contribute to preventing the pathophysiological process of MS. Also, the proposed model could be used as a preventive way on disposed people to multiple sclerosis, particularly in first degree relatives of these patients.
Free full text.
Vitamin D3's anti-inflammatory effect via IL-27 & TGF-B1
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 1551 Views
-
Last post by frodo
-
- 0 Replies
- 2348 Views
-
Last post by frodo
-
- 0 Replies
- 1355 Views
-
Last post by Petr75
-
- 0 Replies
- 1105 Views
-
Last post by Petr75
-
- 0 Replies
- 11073 Views
-
Last post by accordingnature495
-
- 0 Replies
- 1961 Views
-
Last post by NHE
-
- 0 Replies
- 10342 Views
-
Last post by NHE
-
- 0 Replies
- 4643 Views
-
Last post by NHE
-
- 0 Replies
- 1527 Views
-
Last post by frodo