Preventing iron neurotoxicity.
A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology.
Cells. 2022 Jan 27;11(3):440.
Iron deposition in the brain begins early in multiple sclerosis (MS) and continues unabated. Ferrous iron is toxic to neurons, yet the therapies used in MS do not counter iron neurotoxicity. Extracts of Hibiscus sabdariffa (HS) are used in many cultures for medicinal purposes. We collected a distinct HS extract and found that it abolished the killing of neurons by iron in culture; medications used in MS were ineffective when similarly tested. Neuroprotection by HS was not due to iron chelation or anthocyanin content. In free radical scavenging assays, HS was equipotent to alpha lipoic acid, an anti-oxidant being tested in MS. However, alpha lipoic acid was only modestly protective against iron-mediated killing. Moreover, a subfraction of HS without radical scavenging activity negated iron toxicity, whereas a commercial hibiscus preparation with anti-oxidant activity could not. The idea that HS might have altered properties within neurons to confer neuroprotection is supported by its amelioration of toxicity caused by other toxins: beta-amyloid, rotenone and staurosporine. Finally, in a mouse model of MS, HS reduced disability scores and ameliorated the loss of axons in the spinal cord. HS holds therapeutic potential to counter iron neurotoxicity, an unmet need that drives the progression of disability in MS.
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Hibiscus inhibits iron neurotoxicity
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Re: Hibiscus inhibits iron neurotoxicity
Oh wow. Time warp. I wonder if the uric acid lowering effect of hibiscus tea is responsible for the diuretic effect you experienced when drinking it for BP. Also, I don’t have time to search this up but I seem to recall having a goofy idea about the geographic distribution of MS and consumption of hibiscus tea. Interesting. Will have to delve back into this…
Be well.
Be well.
Re: Hibiscus inhibits iron neurotoxicity
I have decided to give the hibiscus tea another trial run to see how it goes.
Re: Hibiscus inhibits iron neurotoxicity
interesting, i hear hibiscus tea and think vitamin C, which makes all the sense in the iron handling arena. i've been needing to supplement iron to keep levels up per specialist's instruction, esp in the face of high zinc intake. i'm also monitoring vit C levels as part of this particular dynamic. the latest specialist is after x thousand mg vit c per day with no specified serum target. meanwhile i'm after tissue sat levels of 70 (don't recall the units off the top of my head) but last levels were 54. work in progress. will consider bringing hibiscus into the mix
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- Family Elder
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Re: Hibiscus inhibits iron neurotoxicity
Are y’all seeking out hibiscus sabdariffa for the iron safety effect? Post any interesting (or boring) results. I might join in the tea club after I’ve exhausted my uric acid curiosity.
Do you suppose you could absorb the tea transdermally…like a vitamin c face mist to protect against daytime free radicals? Just thinking two birds one stone.
Do you suppose you could absorb the tea transdermally…like a vitamin c face mist to protect against daytime free radicals? Just thinking two birds one stone.
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