Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
Int J Nanomedicine. 2019 Jun 17:14:4449-4460.
Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.
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Curcumin nanoparticles in neurological disease
Re: Curcumin nanoparticles in neurological disease
Curcumin Formulations for Better Bioavailability:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/
Re: Curcumin nanoparticles in neurological disease
Thanks for the link to the paper. I hadn't seen that one.DIM wrote: ↑Wed Mar 27, 2024 11:24 pm Curcumin Formulations for Better Bioavailability:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/
I take Longvida Curcumin.
Re: Curcumin nanoparticles in neurological disease
I was giving it to my wife until last year that I found CurQfen is more bioavailable, while Optima C-PC (Longvida + Phosphatidyl Choline) stopped it's production!NHE wrote: ↑Thu Mar 28, 2024 12:21 amThanks for the link to the paper. I hadn't seen that one.DIM wrote: ↑Wed Mar 27, 2024 11:24 pm Curcumin Formulations for Better Bioavailability:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/
I take Longvida Curcumin.
CurQfen has all the natural curcuminoids found in curcumin and if you take it with Turmacin, another bioavailable form of curcumin, you achieve max bioavailability!
This is what I order now: https://www.sunday.de/en/curcumin-ultra ... sules.html
https://www.cambridge.org/core/journals ... 5D45595120
Re: Curcumin nanoparticles in neurological disease
2024 Apr 1
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients
Conclusion: This study demonstrates that curcumin and calcitriol can effectively modulate the inflammatory processes intrinsic to MS by mitigating the expression of inflammatory cytokines by Th1 and Th17 cells while concurrently enhancing the regulatory role of Treg cells. Moreover, the combined treatment of curcumin and calcitriol did not yield superior outcomes compared to single-dosing strategies.
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients
Conclusion: This study demonstrates that curcumin and calcitriol can effectively modulate the inflammatory processes intrinsic to MS by mitigating the expression of inflammatory cytokines by Th1 and Th17 cells while concurrently enhancing the regulatory role of Treg cells. Moreover, the combined treatment of curcumin and calcitriol did not yield superior outcomes compared to single-dosing strategies.
https://www.eboro.cz
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