minocycline vs. doxycycline in CAP protocol

g123 · Post by **g123** » Mon Apr 21, 2008 7:41 pm

Hello,

I have a few questions about using doxy vs. mino in the CAP protocol. So as I understand it:

* Doxy is officially used in the protocol
* Some people use Mino instead
* Mino may have some neuroprotective properties

My questions are:

1. Is there any reason to believe Doxy would be more (or less) effective than Mino? If they are assumed equal, I'd think Mino would have the edge b/c of its possible neuroprotective qualities

2. Is Doxy possibly neuroprotective as well? Maybe those initial studies just happened to be Mino as opposed to other tetracyclines?

3. Is one or the other more difficult to tolerate in terms of side effects?

4. for those of you who have done the CAP, would you recommend one vs. the other?

thanks again

SarahLonglands · Post by **SarahLonglands** » Tue Apr 22, 2008 1:31 am

Doxycycline is neuroprotective as well, its just that there have been a couple of trials with minocycline to this end. Doxycycline is easier to tolerate, so one would assume better for long term use. As a microbiologist David prefers it for this reason. I took it with roxithromycin rather than azithromycin as the second antibiotic. AS far as tissue penetration this s the best of all and is much easier to tolerate.

Sarah

g123 · Post by **g123** » Tue Apr 22, 2008 12:34 pm

Anecdote wrote:Doxycycline is neuroprotective as well, its just that there have been a couple of trials with minocycline to this end. Doxycycline is easier to tolerate, so one would assume better for long term use. As a microbiologist David prefers it for this reason. I took it with roxithromycin rather than azithromycin as the second antibiotic. AS far as tissue penetration this s the best of all and is much easier to tolerate.

Sarah

thank you! do you mean, doxy is better than mino for tissue penetration... or roxithromycin is better than azithromycin is better for tissue penetration?

SarahLonglands · Post by **SarahLonglands** » Wed Apr 23, 2008 4:37 am

Doxy and mino are about the same, but roxi has the most tissue penetration, especially when used in synergy with one of the other two, its also the most easily tolerated. That's why I was prescribed it in the first place.

Sarah

tory2457 · Post by **tory2457** » Fri May 09, 2008 6:26 am

my doctor used Doxy in the beginning...to see if I would react to an antibiotic therapy.

His choice is Mino ( for me and what ailes me). It crosses the BBB. He then switches things up as treatment continues.

I've been on Tetracycline, Roxy ( Love IT) etc. But Mino is a drug he used along with others.