Statins have detrimental effects on remyelination in MS
Simvastatin interferes with process outgrowth and branching of oligodendrocytes.
Statins have attracted interest as a treatment option for multiple sclerosis (MS) because of their pleiotropic antiinflammatory and immunomodulatory effects.
However, contradictory results have been described when they are applied to oligodendrocytes (OLGs), the cell type predominantly affected in MS. In this study we focus on the in vitro effect of statins on process outgrowth in OLN-93 cells, a well-characterized OLG-derived cell line, and primary cultures of neonatal rat OLGs. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1319