Oral MS drug Teriflunomide may boost Glatiramer efficacy

MSUK · Post by **MSUK** » Tue Jun 07, 2011 2:25 am

Adding the investigational, oral drug teriflunomide to glatiramer acetate (GA, Copaxone) in patients with relapsing multiple sclerosis substantially decreased the MRI lesion burden, although the effect on relapse rates was less clear, a researcher said here.

In a 48-week, phase II trial, patients receiving 7 mg/day of teriflunomide in addition to GA had only about one-third the average number of T1-gadolinium-enhancing lesions seen in patients taking placebo plus GA (P=0.03), said Mark Freedman, MD, of the University of Ottawa.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1767

LR1234 · Post by **LR1234** » Tue Jun 07, 2011 2:37 am

I am thinking of starting copaxone.....Does this study suggest in two thirds of people taking copaxone there were still enhancing lesions???? I know this study is meant to be looking at the combo but I am more interested on the efficiency of copaxone plus placebo! Could someone translate for me?

joeymia · Post by **joeymia** » Mon Jun 20, 2011 9:49 am

anyone know if you could just take a regimen of Leflunomide? Leflunomide is pretty cheap. I found this interesting in the wikipedia for Leflunomide

"Teriflunomide can be found as late as 2 years after termination of therapy in human plasma in sufficient levels to cause severe harm to pregnant women or to cause significant interactions."

http://en.wikipedia.org/wiki/Leflunomide

I guess this also means women should be careful.