Dural sinuses

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
Post Reply
User avatar
Petr75
Family Elder
Posts: 1152
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic

Dural sinuses

Post by Petr75 » Wed Feb 03, 2021 12:42 pm

2021 Jan 18
Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, USA
Functional characterization of the dural sinuses as a neuroimmune interface
https://pubmed.ncbi.nlm.nih.gov/33508229/

Abstract

Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this surveillance. Here, we demonstrate that CNS-derived antigens in the cerebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting cells, and are presented to patrolling T cells. This surveillance is enabled by endothelial and mural cells forming the sinus stromal niche. T cell recognition of CSF-derived antigens at this site promoted tissue resident phenotypes and effector functions within the dural meninges. These findings highlight the critical role of dural sinuses as a neuroimmune interface, where brain antigens are surveyed under steady-state conditions, and shed light on age-related dysfunction and neuroinflammatory attack in animal models of multiple sclerosis.

Post Reply

Return to “Chronic Cerebrospinal Venous Insufficiency (CCSVI)”