Geographic MS populations and CCSVI?
Geographic MS populations and CCSVI?
Excuse me while I take my Vitamin D and Omega3 and Flaxseed Oil.
Jim
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Another area I've been interested in documenting, and doctors are testing for this using fMRI BOLD technology pre and post angioplasty, is that CCSVI creates diffuse cerebral hypoxia in MS brains. Being at high altitude creates a more severe hypoxic situation, increasing cellular death and activating the immune system. It was after a week at high altitude that my husband had his first flare...and I believe it's why we see more MS diagnosed in Colorado, etc...but it's still a theory. The venous malformations is scientific fact.
As far as vitamin D--I believe it's related to helping oxygen utilization. Anyone with low vitamin D might suffer more from hypoxic injury. Don't know if it's implicated in congenital venous malformations yet. More studies ahead, I'm sure.
cheer
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
Impact of Hypoxia
I'm so happy they're doing the fMRI BOLD technology pre and post angioplasty. I'm waiting for the results.Another area I've been interested in documenting, and doctors are testing for this using fMRI BOLD technology pre and post angioplasty, is that CCSVI creates diffuse cerebral hypoxia in MS brains. Being at high altitude creates a more severe hypoxic situation, increasing cellular death and activating the immune system.

I know you've mentioned Jeff's high altitude flare several times, but I can't remember if this abstract has ever been posted, so here it is. (Sorry if it's a repeat folks).
Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areas
Since I'm on the topic, here's another one......CONCLUSION: These findings suggest that extremely high-altitude exposures may cause subtle white and grey matter changes that mainly affect brain regions involved in motor activity.
Tolerance to severe hypoxia: lessons from Mt. Everest
I think the fMRI BOLD research pre and post angioplasty could be quite informative.However, there is impairment of central nervous system function at high altitude which persists following return to sea level.
Significant abnormalities of motor coordination persisted for more than 12 months in most members of the Everest expedition.
There is evidence that the climbers who ventilate most at high altitude have the most central nervous system impairment, presumably because of the more severe cerebral vasoconstriction
Take care everyone--
Sharon
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ozarkcanoer
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thanks so much for those studies. Very, very interesting.
Here's the first fMRI BOLD chart of Devin Hubbard. Devin is the son of Dr. David Hubbard, a neurologist in San Diego, CA and a doctor who is now testing for CCSVI and referring to an IR. They have their IRB! This is his son's oxygenation result pre and post angio.
link to chart
Dr. Haacke and Dr. Hubbard are at the forefront of documenting this change in oxygenation. Many more charts to come. So very glad.
cheer
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
Re: Impact of Hypoxia
"Subtle white-and-grey matter changes" sounds a lot like "normal-appearing white matter." (I have been bitter since I learned that phrase, since I would much prefer my white matter to be normal as compared to normal-appearing.) Very interesting links. I canceled a medium-altitude hike this spring because of my concerns over this.Shayk wrote:Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areasCONCLUSION: These findings suggest that extremely high-altitude exposures may cause subtle white and grey matter changes that mainly affect brain regions involved in motor activity.
So, then where are we with out theories and hypotheses??
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http://www.denvermagazine.com/May-2010/ ... -Altitude/The other focus is epidemiology, the effects of hypoxia on lifespan and progression of cancer, heart disease, obesity, lung diseases, and neurological diseases, including Alzheimer’s and multiple sclerosis. Projected studies will investigate multiple sclerosis progression, longevity, cardiovascular disease, and behavior of malaria at altitude. Medical applications for these studies are being realized in conjunction with sophisticated geographic information systems technology that tracks migrations of populations.
Research director Robert Roach, Ph.D., is investigating the brain response to hypoxia and its relation to AMS and the genetics of AMS and human athletic performance. Vaughn Browne, M.D., Ph.D., studies the genetics of low birth-weight babies at altitude, investigating the differences in pregnancy adaptations of women whose ancestors lived in the Bolivian Andes for millennia compared to European women whose ancestors lived at altitude for only a few generations.
ARC scientists are offering their expertise to high-altitude clinical research projects worldwide. Ultimately, experts hope understanding gained through research improves the clinical treatment of problems related to hypoxia.
cheer
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
astronaut - now alzheimers neuroscientist - admitted to the audience
that she herself is as many of her fellow astronauts, quite
concerned about brain injury and the longterm risk of developing dementia diseases from space missions.
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