Dr. Thanaporn's mouse model of CCSVI!!!

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
Cece
Family Elder
Posts: 9335
Joined: Mon Jan 04, 2010 3:00 pm
Contact:

Dr. Thanaporn's mouse model of CCSVI!!!

Post by Cece »

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA
I googled murine, it means mouse! This is the ccsvi mouse model, with mild but significant impairment of gait.

This will be presented at ISNVD next month. Who is Dr. Thanaporn? What do you think, mild impairments in gait, as long as it's significant it is a decent model for ccsvi? I belive they simply ligated both jugulars in the mice, forcing the blood flow to find other ways out from the brain.

Do mice have anything analagous to an azygous?

Someone has said that mice have a 2-year lifespan, is that accurate for these research mice?
pairOdime
Family Elder
Posts: 167
Joined: Sun Dec 05, 2010 3:00 pm
Contact:

Post by pairOdime »

Genetically Determined Variation in the Azygos Vein in the Mouse
http://www.cs.tut.fi/~sanchesr/Biddle/p ... 9_1991.pdf
The normal mouse is expected to have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava.
It's a paradigm shift
pairOdime
Family Elder
Posts: 167
Joined: Sun Dec 05, 2010 3:00 pm
Contact:

Post by pairOdime »

Dr. Porama Thanaporn
http://cvmedicine.stanford.edu/vascular ... s.html#koy
Porama Koy Thanaporn joined the Section of Vascular Medicine in the Division of Cardiovascular Medicine as clinical fellow in 2008. Koy received his undergraduate degrees in Bioengineering and Biology at the University of Pennsylvania summa cum laude where he was a Benjamin Franklin Scholar and was elected to Tau Beta Pi Engineering Honor Society.

Dr. Thanaporn connected with Dr. John Cooke’s (specialist in Vascular Medicine and endothelial biologist) research team at Stanford. Here is the link for Dr. Cooke.

http://cvmedicine.stanford.edu/vascular ... outus.html
It's a paradigm shift
User avatar
cheerleader
Family Elder
Posts: 5361
Joined: Mon Sep 10, 2007 2:00 pm
Location: southern California

Post by cheerleader »

Yup...that's my hero, Dr. Cooke and his colleague at Stanford. He read the Endothelial Health program I'd created for Jeff in the fall of 2009. It was based on his research for The Cardiovascular Cure. He wrote me back and we became e-mail correspondents. When the Zamboni paper was released in December '09, I sent it to him to read, and he said he thought there was something to it. He then gave the paper to Michael Dake, his office neighbor at Stanford. Dr. Dake read the paper and ended up meeting Dr. Zamboni at the Charing Cross Vascular Symposium the next week-- then coming home to Stanford and calling us up to test Jeff.

It's all still a bit extraordinary to me...I call it divine providence, others might call it coincidence. But I'm proud to know Stanford is continuing to study this.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
codefellow
Family Elder
Posts: 120
Joined: Tue Nov 18, 2008 3:00 pm
Contact:

Post by codefellow »

Clearly, the mouse and the researchers are deluding themselves with a reverse-placebo effect. The mouse knows its veins have been altered, and it wants to please the researchers, who know exactly what they are hoping to see, and so the mouse limps a little.

The only way this test will ever prove anything is if you have one standard mouse, one with EAE, and one with the synthesized CCSVI, and of course, no one, researchers or mice or those collecting the results, can know which is which.

In other words, you have to at least use THREE BLIND MICE!!

:P

(This contributes nothing to the discussion, so I fully expect the moderator to delete it soon, but if it provides a couple of smiles before that, so be it.)
User avatar
MS_HOPE
Family Elder
Posts: 133
Joined: Fri Jun 11, 2010 2:00 pm
Location: North Carolina, USA
Contact:

Post by MS_HOPE »

codefellow, you got me smiling! I love you guys.
CCSVI:  Making Sense of MS
User avatar
1eye
Family Elder
Posts: 3780
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada
Contact:

Post by 1eye »

codefellow wrote: :P

(This contributes nothing to the discussion, so I fully expect the moderator to delete it soon, but if it provides a couple of smiles before that, so be it.)
Saw it, smiled. :D
This unit of entertainment not brought to you by FREMULON.
Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
AlmostClever
Family Elder
Posts: 366
Joined: Mon Dec 21, 2009 3:00 pm
Location: Houston, TX
Contact:

Post by AlmostClever »

Any mention of MS-like lesions or iron deposition?
If you can't explain it simply, you don't understand it well enough. - Al Einstein
User avatar
garyak
Family Elder
Posts: 314
Joined: Sun May 30, 2010 2:00 pm
Location: grande prairie , alberta,canada
Contact:

Post by garyak »

8) :D
User avatar
mavis
Family Member
Posts: 78
Joined: Sun Sep 26, 2010 2:00 pm
Contact:

Post by mavis »

Lots of :lol: from me too. Very much appreciated on a day like I'm having.
User avatar
prairiegirl
Family Elder
Posts: 228
Joined: Fri Feb 05, 2010 3:00 pm

Post by prairiegirl »

Contributions to smiles appreciated here 8) !
User avatar
MrSuccess
Family Elder
Posts: 922
Joined: Fri Sep 18, 2009 2:00 pm

Post by MrSuccess »

study must be reviewed by skeptical mice .... in order to validate the results .





Mr. Success
Cece
Family Elder
Posts: 9335
Joined: Mon Jan 04, 2010 3:00 pm
Contact:

Post by Cece »

three blind mice - love it!!!
User avatar
ozarkcanoer
Family Elder
Posts: 1273
Joined: Thu Oct 15, 2009 2:00 pm
Location: St. Louis, Missouri
Contact:

Post by ozarkcanoer »

Cece.... Where is Dr Thanaporn's paper that you quoted from !!!! This is the biggest news since Dr Zamboni's original paper and we would all love to read it. I know I (who have had the procedure) knew that the mouse model would be a turning point.

ozarkcanoer
User avatar
ppicklee
Family Member
Posts: 82
Joined: Sun Jan 10, 2010 3:00 pm
Contact:

Post by ppicklee »

Saw it and smiled. Thanks! :-)
Post Reply
  • Similar Topics
    Replies
    Views
    Last post

Return to “Chronic Cerebrospinal Venous Insufficiency (CCSVI)”