Picamilon - Niacin for the brain (ie Vasodilator)

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CureOrBust
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Picamilon - Niacin for the brain (ie Vasodilator)

Post by CureOrBust »

I haven't looked into it too far at this stage, but after stumbling across it, the links are looking interesting.

https://en.wikipedia.org/wiki/Picamilon
Picamilon is able to cross the blood–brain barrier[5] and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.[6] The second released component, niacin acts as a strong vasodilator,[7] which might be useful for the treatment of migraine headaches.[8][9]
http://www.calmclinic.com/anxiety/drugs/picamilon This one is mostly on anxiety
...Taken on its own, Niacin is a water-soluble B vitamin that easily crosses the blood-brain barrier. It functions to protect neurons against the effects of diminished blood flow...Because this drug can easily penetrate the blood-brain barrier,improve brain blood flow ...
http://smart-drugs.net/info-picamilon.htm Here they are trying to sell the stuff
...Studies show that Picamilon dramatically increases blood flow and circulation within the brain...Picamilon increases blood supply and functional state of the brain, increases microcirculation and hemodynamics of the eyes... and vasoactive agent for acute ischemic disturbances of the cerebral blood circulation of mild to moderate severity...In opthalmological practice, for primary open-angle glaucoma with normalized intraocular pressure, and for diseases of the retina and the optic nerve....
It was also mentioned in another post on this web site by "search" at http://www.thisisms.com/forum/general-d ... ml#p189474

Anyone have any personal experience to share?
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by CaliReader »

No personal experience yet, but I'm going to add this supplement.

It crosses the blood brain barrier and calms inflammation in the brain.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823917/ full text available. Proc Natl Acad Sci U S A >v.107(6); Feb 9, 2010 >PMC2823917
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by PointsNorth »

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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by daniel »

Anyone notice any results so far from Picamilon? (And if so, at what dosages?)
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by ConstableComfortable »

I've taken Picamilon(100mg 'Mind Nutrition' brand) a few times before sleep and found it did act as a relaxant. I was a little fluffy the next morning for an hour or so too. The blurb on the side says to take 1 'for a calm relaxed feeling' and to take '2-3 to increase mental energy'. How that works I'm not sure and have not tested the increased dosage out.
I don't have any major MS symptoms as yet (diagnosed RRMS 5 years ago - I was just hoping for a good nights sleep. Can't say it was a better nights sleep but will try again in the future
I go for NUCCA adjustments every couple of months and the times I tried it I'm sure my atlas (C1) was out so could have not worked as fully or as it should have?? I've just been adjusted so maybe I'll try one soon and compare.
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by 1eye »

Lowers Blood Pressure

The effect of Picamilon on cerebral blood flow was compared with that of papaverine and complamin. The scientists found that Picamilon had a stronger blood pressure-lowering effect than papaverine; complamin mainly affects the peripheral circulation, and it exhibits neither tranquilizing nor stimulating properties.

Picamilon is an approved drug in Russia. It is intended for use in adults as a vasoactive (effecting the caliber of blood vessels) and nootropic (benefiting cognition and nerves) agent for acute cerebrovascular disturbances of mild severity, chronic cerebrovascular insufficiency, and vegetovascular dystonia (an imbalance between sympathetic and parasympathetic influences on vascular tone). The drug is indicated as a tranquilizer for states of anxiety, fear, increased irritability and emotional stress. Picamilon is recommended for depressive disorders in the elderly and for senile psychoses. In management of drug addictions, the compound can be used to abolish withdrawal symptoms in chronic alcoholics. Picamilon is supplied in 0.01, 0.02, and 0.05 gram tablets. It has a useful shelf life of three years.
This is good to know as it may combine with ED drugs or nitroglycerine and cause heart trouble.
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by THX1138 »

https://allnaturalideas.com/picamilon/
The Latest Insight and Controversy About Picamilon

Lisa 
All Natural Ideas
Although made from simple dietary supplements, Picamilon has been banned in the United States. However, it has proven benefits with minimal side effects. 
Why would a beneficial substance made from dietary ingredients be targeted by the FDA? Is there more to the story surrounding controversy?
What is Picamilon?
Picamilon is a unique nootropic compound that is created through the synthetic combination of gamma-Aminobutyric acid (GABA) and niacin. Nootropics are drugs used to enhance memory and other mental and cognitive functions.
It was first developed in Russia in the early 1970s to treat a range of neurological conditions. Go forward some 40 years and the story of the substance is a little different. The FDA has since deemed this powerful nootripic illegal but why?
What Are the Benefits of Picamilon?
Picamilon has the unique advantage of being able to cross the blood-brain barrier due to its niacin component. The GABA component aids in the reduction of stress and anxiety.
Some researchers believe it can help to eliminate certain toxins from the brain via its antioxidant properties in a way that few other compounds can do.
Research has shown that both learning and memory can be improved. And in longer term studies, it was found that long-term memory can also be improved with this substance.
The overall result is a better quality of attention, better retention, learning, and in time- even enhanced mental stamina and cognitive function.
Picamilon has been used to treat brain infections, glaucoma, migraines, severe alcohol intoxication, and even senile psychosis with great success for many years. It is widely considered safe as long as the recommended dosage is adhered to.

Picamilon Side Effects
Picamilon is considered safe for the majority of patients, while a minority experience some unpleasant side effects which include the following:
Dizziness
Headaches
Nausea
Lightheadedness
Skin rash
Low blood pressure
These side effects are uncommon and are rarely dangerous. Users who experience low blood pressure should cease taking the drug and consult a doctor.
Anyone with a cardiovascular or heart condition should consult a physician before using the medication. And, a medical professional should monitor these patients closely during use.
Targeted by the FDA
Despite the clear benefits and low risks of Picamilon, the FDA has placed this substance under its cross-hairs- erasing a nearly $8 billion section of the global nutritional supplement industry.
This has drawn severe criticism. The refusal of the FDA to lend its approval to this proven drug appears to be timed with the 2024 release of a fully synthetic version of the drug by Eli Lily called Solanzumab.
The Argument Against Picamilon
While Picamilon has been in wide use throughout the world, and especially in Russia, and has a long history of delivering proven positive effects on the functioning of the brain- many are comparing it to cannabinoids as the reason to suspend its approval.
There is also some lingering fear of any substance that has the ability to cross and carry other substances through the all-important blood-brain barrier.
While these fears may be understandable, the statistics remain clear and show that the risk factors are extremely low- rivaling those of marijuana, which is gaining increasing acceptance in many forms despite decades of severe demonization.

Recommended Picamilon Dosage per Use
The substance is generally very well tolerated. However, most professionals advise due caution as it directly affects brain chemistry and neurochemical function.
The drug is best known for improving mood, relieving anxiety, and promoting sleep. For these conditions, the recommended dosages are between 50 and 300 mg per day.
Users should begin with the lowest recommended dose. Dose can be gradually increased by 5 to 10 mg a day until the desired effect was achieved.
Should any side effects would of emerged, the dosage should have been reduced, or eliminated. Anyone who experienced low blood pressure should have ceased use immediately and consult their doctor.
Current Legal Status
Picamilon continues to be consumed by controversy. It’s now illegal in the United States. Those who previously supplied it were forced to remove it entirely from their inventories.
It is not very common that local municipal and state laws makers would stop on a dime and about face on their position. However, no criminal charges have resulted against any merchants selling it. And, many influential and well-informed parties are working to promote the acceptance of this beneficial drug.
It’s unclear what the future of this fascinating substance will be. But, you can be sure that there will be a demand for it for as long as the literature describes benefits that far outweigh the risks.
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Re: Picamilon - Niacin for the brain (ie Vasodilator)

Post by NHE »

THX1138 wrote:https://allnaturalideas.com/picamilon/
The Latest Insight and Controversy About Picamilon
----------------------------------------------------------
Despite the clear benefits and low risks of Picamilon, the FDA has placed this substance under its cross-hairs- erasing a nearly $8 billion section of the global nutritional supplement industry.
This has drawn severe criticism. The refusal of the FDA to lend its approval to this proven drug appears to be timed with the 2024 release of a fully synthetic version of the drug by Eli Lily called Solanzumab.
This statement appears to be incorrect. Solanzumab is a monoclonal antibody that binds amyloid beta which has been tested as a possible treatment in Alzheimer's Disease.

https://en.wikipedia.org/wiki/Solanezumab
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