VitD and Endothelial Health

[PointsNorth]

http://www.vitamindcouncil.org/blog/rec ... 1ca034eaa9#

Comment from my bud Ed:

The key hormone directing the growth and differentiation of blood vessels is calcitriol.

This is mostly likely why pwMS end up with screwed up veins when you look at the combination of the latitude and birth month effects. If the mother is vitamin D deficient as is likely at the point in fetal development at which veins are formed, 7th-8th month, then you end up with the congential defects characteristic of CCSVI.

Vitamin D then seems to inherit the role of controlling and maintaining the blood vessels it creates. It triggers contraction and relaxation by control over NO. It directs the local, adaptive immune response to infection or injury such that if these occur later in life at a time of vitamin D deficiency, then the body is unable to manage the response to infection or injury to blood vessels.

D is the alpha and omega of veins and arteries and to the extent that this is a major factor in MS, it is certainly a key consideration in maintaining endothelial health and function.