Cerebral Vasculitis is prerequisite for MS Lesion Genesis

[frodo]

https://www.researchgate.net/profile/Ch ... 473044.pdf

The classic acute inflammatory response is typified by a mandatory vascular inflammation and there is considerable
evidence conclusively demonstrating cerebral vasculitis in early MS pathology.

[1eye]

This fact is being used to justify use of the animal EAE model to research MS. I think the model of using CSF from MS patients on animals is much closer to a model of what actually happens in MS. Perhaps Cerebral Vasculitis is a prerequisite for a mouse to develop EAE, and perhaps it happens mostly to mouse veins, and not arteries, as it does in human MS, but wouldn't we be better served by trying the MS-CSF model on other mammals?

[frodo]

This fact is being used to justify use of the animal EAE model to research MS.

Your right. I was expecting something more when I read the title.

But at least, they acknowledge the importance of vascular inflammation in MS