blood coagulation factors linked again to MS

[frodo]

This time, the factors linked to MS are prothrombin (https://en.wikipedia.org/wiki/Thrombin) and factor X (https://en.wikipedia.org/wiki/Factor_X). Interestingly, PPMS and NMO patients did not show this profile.

Prothrombin and factor X are elevated in multiple sclerosis patients.
https://www.ncbi.nlm.nih.gov/pubmed/27774643

Animal models have implicated an integral role for coagulation factors in neuroinflammatory diseases like multiple sclerosis (MS) beyond their role in hemostasis. However, their relevance in humans requires further elucidation. This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing-remitting and secondary-progressive MS had significantly higher prothrombin and factor X levels than healthy donors (HD), while levels were unchanged in primary-progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies. This article is protected by copyright. All rights reserved.